An initial–boundary-value problem for the nonlinear equations of real compressible viscous heat-conducting flow with general large initial data is investigated. The main point is to study the real flow for which the pressure and internal energy have nonlinear dependence on temperature, unlike the linear dependence for ideal flow, and the viscosity coefficients and heat conductivity are also functions of density and/or temperature. The shear viscosity is also presented. The existence, uniqueness and regularity of global solutions are established with large initial data in H1. It is shown that there is no shock wave, vacuum, mass concentration, or heat concentration (hot spots) developed in a finite time, although the solutions have large oscillations.