The study of the multiplicity of massive stars gives hints of their formation processes and their evolution path. Optical interferometry is mandatory to fulfill our knowledge of their multiplicity by probing the separation gap between 1 and 50 mas. We demonstrated the capability of the new interferometric instrument MIRC-X, located at the CHARA array, to study a large sample of more than 120 (H < 7.5) O-type stars. We observed 29 O-type star systems, including a couple of systems in average atmospheric conditions around a magnitude of H = 7.5. Out of these 29 systems, we detected 18 companions in 16 different systems, resulting in a multiplicity fraction fm = 16/29 = 0.55, and a companion fraction of fc = 18/29 = 0.62. We observed for the first time 11 of these detected companions. This study concludes that a large survey on more than 120 Northern O-type stars is possible with MIRC-X.