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Two myostatin single nucleotide polymorphisms have significant effects on muscle depth of British commercial Charollais sheep

Published online by Cambridge University Press:  23 November 2017

G. Hadjipavlou ,
O. Matika ,
A. Clop  and
S.C. Bishop
G. Hadjipavlou*
Affiliation:
Roslin Institute (Edinburgh), Roslin, Midlothian EH25 9PS, United Kingdom Institute of Evolutionary Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
O. Matika
Affiliation:
Roslin Institute (Edinburgh), Roslin, Midlothian EH25 9PS, United Kingdom
A. Clop
Affiliation:
Genesis Faraday Partnership, Roslin, Midlothian EH25 9PS, United Kingdom
S.C. Bishop
Affiliation:
Roslin Institute and Royal (Dick) School of Veterinary Studies, Roslin BioCentre, Midlothian EH25 9PS, United Kingdom
*
Email:georgia.hadjipavlou@bbsrc.ac.uk
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Extract

In 2006, myostatin single nucleotide polymorphisms (SNPs) were identified on ovine chromosome 2 (OAR2), with two SNPs (g-2449C-G and g+6723G-A) having significantly higher frequency in hyper-muscled Belgian Texel than in control animals (Clop et al., 2006). In particular, the A allele of the g+6723G-A SNP was proposed to be a causative mutation for increased muscularity in Texel rams (Clop et al., 2006). We aimed to assess whether the above two SNPs were present in UK commercial Texel, Suffolk and Charollais breeds. Moreover, we performed association analysis of the SNP effects on phenotypes in an extended UK commercial population of Charollais sheep in order to further evaluate the SNP contribution to muscle and fat tissue composition, and to quantify and fully characterise the SNP effects in this breed.

Type
Theatre Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2008 , 2008 , pp. 68
Copyright
Copyright © The British Society of Animal Science 2008

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References

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