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The role of P450IIE1 protein and mRNA expression in determining adipose tissue skatole level

Published online by Cambridge University Press:  20 November 2017

E. Doran ,
F. Whittington ,
J.D. Wood  and
J.D. McGivan
E. Doran
Affiliation:
Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, U.K.
F. Whittington
Affiliation:
Department of Clinical Veterinary Science, School of Veterinary Science, Langford, University of Bristol, Bristol BS40 5DU, UK
J.D. Wood
Affiliation:
Department of Clinical Veterinary Science, School of Veterinary Science, Langford, University of Bristol, Bristol BS40 5DU, UK
J.D. McGivan
Affiliation:
Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, U.K.
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Extract

High concentrations of skatole in adipose tissue are a major factor in boar taint - the offensive odor and taste in cooked pork from some intact male pigs. Skatole is produced by bacterial fermentation of tryptophan in the large intestine, absorbed into the blood and transported into the liver, where it can be metabolised via the cytochrome P450 system. One reason for high skatole levels in pig adipose tissues could be low expression of hepatic cytochrome P450IIE1 in liver and hence a reduced rate of skatole clearance, but no correlation was found between the rate of skatole metabolism and the P450IIE1 content of isolated liver microsomes. The present study re-investigates the relationship between backfat skatole, liver P450IIE1 expression and the rate of microsomal skatole metabolism in two breeds of pigs.

Type
Poster Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2001 , 2001 , pp. 74
Copyright
Copyright © The British Society of Animal Science 2001

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