Hostname: page-component-848d4c4894-tn8tq Total loading time: 0 Render date: 2024-06-24T23:21:53.755Z Has data issue: false hasContentIssue false
  • English
  • Français

Ontogeny of factors thought to control the development of ovine muscle in utero

Published online by Cambridge University Press:  20 November 2017

A.J. Fahey ,
J.M. Brameld ,
T. Parr  and
P.J. Buttery
A.J. Fahey*
Affiliation:
Division of Nutritional Biochemistry, School of Biosciences, Sutton Bonington Campus, The University of Nottingham, Leicestershire, LE12 5RD, U.K.
J.M. Brameld
Affiliation:
Division of Nutritional Biochemistry, School of Biosciences, Sutton Bonington Campus, The University of Nottingham, Leicestershire, LE12 5RD, U.K.
T. Parr
Affiliation:
Division of Nutritional Biochemistry, School of Biosciences, Sutton Bonington Campus, The University of Nottingham, Leicestershire, LE12 5RD, U.K.
P.J. Buttery
Affiliation:
Division of Nutritional Biochemistry, School of Biosciences, Sutton Bonington Campus, The University of Nottingham, Leicestershire, LE12 5RD, U.K.
*
Email: sbxajf@nottingham.ac.uk
Get access

Extract

It is believed that there are time periods during the lifetime of an animal when inadequate nutrition may result in the animal not reaching its genetic potential. One sensitive period is during early foetal life at the time when muscle fibres are being formed from myogenic cells. The total numbers of muscle fibres for life are essentially set during this period. The aim of this study was to try and identify the ontogeny of muscle cell differentiation by quantifying the mRNA expression of ovine IGF-I, ovine IGF-II, and ovine myogenin, factors known to influence myoblast proliferation or differentiation. The aim was to gain an indication of the time period during gestation at which differentiation of the muscle cells commences. The period before differentiation (i.e. during proliferation) is potentially sensitive to external factors, such as nutrient supply. This information could be used to determine the time during pregnancy when adequate feeding is essential to ensure maximum muscle development of the offspring, and may allow the manipulation of diet to change muscle characteristics for meat production.

Type
Poster Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2003 , 2003 , pp. 95
Copyright
Copyright © The British Society of Animal Science 2003

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Brameld, J.M, Buttery, P.J, Dawson, J.M and Harper, J.M.M (1998) Nutritional and hormonal control of skeletal muscle cell growth and differentiation. Proceedings of the Nutrition Society 57: 207–217.Google Scholar
Dickson, M.C., Saunders, J.C. and Gilmour, R.S. (1991) The ovine IGF-I gene-characterisation, expression and identification of a putative promoter. Journal of Molecular Endocrinology 6: (1) p17–31.CrossRefGoogle Scholar
Hasty, P., Bradley, A., Morris, J.A., Edmondson, D.G., Venuti, J.M., Olsen, E.N., and Klein, W.H (1993). Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Nature 364: 501–506.CrossRefGoogle ScholarPubMed