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A missense mutation in the bovine leptin gene in Iranian Taleshi cattle

Published online by Cambridge University Press:  23 November 2017

Mohammad Reza Nassiry ,
Alireza Heravi Moussavi ,
Ali Javadmanesh ,
Saheb Foroutani Far  and
Reza Pourseifi
Mohammad Reza Nassiry*
Affiliation:
Center of Excellence for Animal Science-Ferdowsi University of Mashad, Mashad, Iran
Alireza Heravi Moussavi
Affiliation:
Center of Excellence for Animal Science-Ferdowsi University of Mashad, Mashad, Iran
Ali Javadmanesh
Affiliation:
Center of Excellence for Animal Science-Ferdowsi University of Mashad, Mashad, Iran
Saheb Foroutani Far
Affiliation:
Center of Excellence for Animal Science-Ferdowsi University of Mashad, Mashad, Iran
Reza Pourseifi
Affiliation:
Center of Excellence for Animal Science-Ferdowsi University of Mashad, Mashad, Iran
*
Email:m_nassiry@yahoo.com
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Extract

Candidate gene approaches facilitate discovering and localizing causative genes for quantitative traits and polymorphisms within selected candidate genes can be tested for association with variationin the quantitative trait (Campbell et al., 2003). Leptin is a 16-kDa protein that is synthesized and secreted predominantly by white adipocytes tissue and its expression is regulated by body fatness and energy balance. Leptin gene expressed in a variety of tissues including adipose tissue, placenta, mammary glands, skeletal muscles, gastric mucosa, brain and pituitary glands. In cattle, the leptin gene is located on chromosome 4 and consists of three exons. Several studies shown the association between polymorphism at the leptin gene and feed intake, energy balance, fertility and immune functions. It has been shown that leptin gene influences milk performance in cattle and reproduction in beef cattle(Liefers et al., 2002). Buchanan et al. (2002) described a cytosine (C) to thymine (T) substitution in exon 2 of the leptin gene of the B. taurus breeds, suggesting the existence CC, TT and CT genotypes. The aim of this study was to identify the single nucleotide polymorphism of exon 2 in Iranian Taleshi cattle.

Type
Poster Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2007 , April 2007 , pp. 155
Copyright
Copyright © The British Society of Animal Science 2007

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References

Buchanan, F. C., Fitzsimmons, C. J., Van Kessel, A. G., Thue, T. D., Sim, D. C. Winkelman and Schmutz, S. M. 2002. Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels. Genet Sel Evol. 34: 105–116.Google Scholar
Campbell, E.M., Nonneman, D. and Rohrer, G.A., 2003. Fine mapping a quantitative trait locus affecting ovulation rate in swine on chromosome 8. J. Anim. Sci. 81: 1706–1714.Google Scholar
Liefers, S. C., Veerkamp, R. F., te Pas, M. F., Delavaud, C., Chilliard, Y., Platje, M. and van der Lende, T. 2005. Leptin promoter mutations affect leptin levels and performance traits in dairy cows. Animal Genetics. 36: 111–118.Google Scholar