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Genomic contributions in a cattle introgression program

Published online by Cambridge University Press:  20 November 2017

E.E. Wall
Affiliation:
Institute of Ecology & Resource Management, University of Edinburgh, Edinburgh EH9 3JG, UK
J.A. Woolliams
Affiliation:
Roslin Institute, Roslin, Midlothian EH25 9PS, UK
P.M. Visscher
Affiliation:
Institute of Ecology & Resource Management, University of Edinburgh, Edinburgh EH9 3JG, UK
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Extract

Not all commercial lines and breeds contain the best alleles for genes of economic importance. Introgression strategies transfer a gene from a non-commercial source to a commercial line by incorporating the favourable allele of a gene from the donor animals whilst retaining beneficial alleles affecting commercial traits in the recipient animals. This is achieved through generations of backcrossing and the resulting heterozygotes are selected and intercrossed to produce animals homozygous for the gene of interest. Animals produced from an introgression program can be inferior to commercial animals because of the contribution from the donor genome at loci not under selection. This genetic lag experienced in an introgression program can be partly attributed to the intercross as a higher number of animals are selected primarily upon genotype thereby reducing the selection intensity for other traits (Visscher and Haley, 1999). The chromosome segment containing the desired introgressed gene (linkage drag) can be quite large, e.g., 32 cM for a 100 cM chromosome in backcross 6 (Stam and Zeven, 1981). The aim of this study is to examine the genomic contribution of each generation to animals produced after the intercross and the level of homozygosity.

Type
Theatre Presentations
Copyright
Copyright © The British Society of Animal Science 2000

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References

Stam, P. & Zeven, A.C. (1981). The theoretical proportion of the donor genome in near isogenic lines of self-fertilizers bred by backcrossing. Euphtica, 30: 227238.Google Scholar
Visscher, P.M. & Haley, C.S. (1999). On the efficiency of marker-assisted introgression. Animal Science, 68: 5968.Google Scholar