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Effect of increasing stearoyl coenzyme A desaturase mRNA concentrations using forage and concentrate diets on the fatty acid composition of ovine adipose tissue

Published online by Cambridge University Press:  20 November 2017

Z.C.T.R. Daniel ,
R.J. Wynn ,
A.M. Salter  and
P.J. Buttery
Z.C.T.R. Daniel
Affiliation:
Division of Nutritional Biochemistry, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, U.K.
R.J. Wynn
Affiliation:
Division of Nutritional Biochemistry, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, U.K.
A.M. Salter
Affiliation:
Division of Nutritional Biochemistry, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, U.K.
P.J. Buttery
Affiliation:
Division of Nutritional Biochemistry, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, U.K.
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Extract

Compared to meat from other animals lamb contains high levels of saturated fat, particularly stearic acid which comprises 18% of the total fatty acids (Enser et al, 1996). This stearic acid can be desaturated in the tissue by stearoyl coenzyme A desaturase (SCD) to produce oleic acid. In sheep SCD is produced from a single gene and the levels of SCD mRNA in the tissue correlate well with oleic acid (Ward et al, 1998, Barber et al, 2000) suggesting that an upregulation of SCD activity may increase the relative proportions of unsaturated and saturated fatty acids and so significantly improve the nutritional quality of sheep meat. Our recent studies have shown that insulin increases SCD mRNA levels and monounsaturated fatty acid synthesis in cultured ovine adipose tissue explants (Daniel et al, 2001). The present study was designed to investigate whether feeding a diet believed to manipulate SCD mRNA concentrations would significantly alter the fatty acid composition of lamb.

Type
Poster Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2002 , 2002 , pp. 206
Copyright
Copyright © The British Society of Animal Science 2002

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References

Barber, M.C., Ward, R.J., Richards, S.E., Salter, A.M., Buttery, P.J., Vernon, R.G. and Travers, M.T. 2000. Ovine adipose tissue monounsaturated fat content is correlated to depot-specific expression of the stearoyl-CoA desaturase gene. Journal of Animal Science 78, 62–68 CrossRefGoogle ScholarPubMed
Daniel, Z.C.T.R., Buttery, P.J. and Salter, A.M. 2001. Effects of insulin and dexamethasone on stearoyl coenzyme A desaturase mRNA concentrations in ovine adipose tissue. Proceedings of the Nutrition Society, In Press.Google Scholar
Enser, M., Hallet, K., Hewitt, B., Fursey, G.A.J. and Wood, J.D. 1996. Fatty acid content and consumption of English beef, lamb and pork at retail. Meat Science 42, 443–456 Google Scholar
Ward, R.J., Travers, M.T., Richards, S.E., Vernon, R.G., Salter, A.M., Buttery, P.J. and Barber, M.C. 1998. Stearoyl CoA desaturase mRNA is transcribed from a single gene in the ovine genome. Biochimica et Biophysica Acta 1391, 145–156 Google Scholar