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Acute and Chronic effects of ß-Agonist Treatment on Calpastatin Gene Expression and Muscle Growth in Sheep.

Published online by Cambridge University Press:  24 November 2017

P.A. Speck ,
K.M. Collingwood ,
R.G. Bardsley ,
R.S. Gilmour ,
G.A. Tucker  and
P.J. Buttery
P.A. Speck
Affiliation:
Dept. Applied Biochemistry and Food Science, University of Nottingham, Faculty of Agriculture and Food Science, Sutton Bonington, LEICS. LE12 5RD.
K.M. Collingwood
Affiliation:
AFRC-IAPGR, Cambridge Research Station, Babraham, Cambridge, CB2 4AT.
R.G. Bardsley
Affiliation:
Dept. Applied Biochemistry and Food Science, University of Nottingham, Faculty of Agriculture and Food Science, Sutton Bonington, LEICS. LE12 5RD.
R.S. Gilmour
Affiliation:
AFRC-IAPGR, Cambridge Research Station, Babraham, Cambridge, CB2 4AT.
G.A. Tucker
Affiliation:
Dept. Applied Biochemistry and Food Science, University of Nottingham, Faculty of Agriculture and Food Science, Sutton Bonington, LEICS. LE12 5RD.
P.J. Buttery
Affiliation:
Dept. Applied Biochemistry and Food Science, University of Nottingham, Faculty of Agriculture and Food Science, Sutton Bonington, LEICS. LE12 5RD.
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Extract

There is a multitude of physiological and metabolic effects that could occur in animals fed ß adrenergic agonists. Many of these could contribute directly or indirectly to the repartitioning effect. ß-agonists are known to stimulate muscle hypertrophy at least partially by reducing the rate of myofibrillar degradation. It is presumed that the changes in muscle growth are associated with changes in the calpain system, which includes the calpain specific inhibitor, calpastatm. Parr et al., (1992) demonstrated a significant effect of ß agonist treatment on calpastatin gene expression in cattle when measurements were made on day 42 of treatment. The present study was conducted to assess the acute and chronic effects of ß; agonist treatment on muscle growth and calpastatin (both in terms of gene expression and enzyme activity), the interpretation of which would provide an insight into the role of the calpain system in muscle growth.

Type
The Application of Molecular Biology to Animal Science
Information
Proceedings of the British Society of Animal Production (1972) , Volume 1993: Winter meeting , March 1993 , pp. 158
Copyright
Copyright © The British Society of Animal Production 1993

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References

Higgins, J.A., Lasslett, Y.V., Bardsley, R.G. and Buttery, P.J. (1988). The relation between dietary restriction or clenbuterol (a selective ß2 agonist) treatment on muscle growth and calpain proteinase (EC 3.4.22.17) and calpastatin activities in lambs. British Journal of Nutrition 60, 645–652.Google Scholar
Parr, T., Bardsley, R.G., Gilmour, R.S. and Buttery, P.J. (1992). Changes in calpain and calpastatin mRNA mduced by ß-adrenergic stimulation of bovine skeletal muscle. European Journal of Biochemistry 208, 333–339.Google Scholar