This paper is intended to provide a rather brief, suggestive, though not very precise, analysis of the significance of “contextualism” for “meaning”, and more specifically of the significance of “systematic (contextual) simplicity” in relation to “meaningful operations” in the language of natural science. The notion of “equivalent theories” is examined in conjunction with the question of simplicity, and finally, these ideas are brought to bear upon “realism” and “semantic realism” in particular. The pragmatic-aesthetic question of the role of simplicity in scientific theories is of some concern to philosophers of science. Henry Margenau (7:96) has pointed out that, among the metaphysical (epistemological) requirements of scientific theories, the “most embarrassing … is one which is often called the postulate of simplicity….” When a topic is embarrassing, the best way to help remove such embarrassment is to indulge further in frank and open discussion of the topic. This I have tried to do in what follows.