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Model Organisms as Models: Understanding the ‘Lingua Franca’ of the Human Genome Project

Published online by Cambridge University Press:  01 April 2022

Rachel A. Ankeny
Rachel A. Ankeny*
Affiliation:
University of Sydney
*
†Send requests for reprints to the author, Unit for History and Philosophy of Science, Carslaw F07, University of Sydney, NSW 2006, Australia; email: r.ankeny@scifac.usyd.edu.au.
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Abstract

Through an examination of the actual research strategies and assumptions underlying the Human Genome Project (HGP), it is argued that the epistemic basis of the initial model organism programs is not best understood as reasoning via causal analog models (CAMs). In order to answer a series of questions about what is being modeled and what claims about the models are warranted, a descriptive epistemological method is employed that uses historical techniques to develop detailed accounts which, in turn, help to reveal forms of reasoning that are explicit, or more often implicit, in the practice of a particular field of scientific study. It is suggested that a more valid characterization of the reasoning structure at work here is a form of case-based reasoning. This conceptualization of the role of model organisms can guide our understanding and assessment of these research programs, their knowledge claims and progress, and their limitations, as well as how we educate the public about this type of biomedical research.

Type
Philosophy of Biology and Cognition
Information
Philosophy of Science , Volume 68 , Issue S3: No. 3 Supplement: Proceedings of the 2000 Biennial Meeting of the Philosophy of Science Association. Part I: Contributed Papers Sep., 2001 , 2001 , pp. S251 - S261
Copyright
Copyright © Philosophy of Science Association 2001

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Footnotes

‡

Thanks to participants at the 1999–2000 Workshop on Model Systems, Cases, and Exemplary Narratives in Science and History, Program in the History of Science, Princeton University, especially Angela Creager, Jane Hubbard, and Mary Morgan, as well as attendees at the 1999–2000 Seminar Series on Model Organisms, Center for the Philosophy of Science and Program in Science and Technology Studies, University of Minnesota for helpful comments on earlier versions of this paper. I also gratefully acknowledge support of preliminary research for this project through a dissertation grant from the Science and Technology Studies Program of the National Science Foundation (NSF #9617211).

References

Ankeny, Rachel A. (1997), The Conqueror Worm: An Historical and Philosophical Examination of the Use of the Nematode C. elegans as a Model Organism. PhD Dissertation. Pittsburgh, PA: University of Pittsburgh.Google Scholar
Ankeny, Rachel A. (1999), “Model Organisms as Case-Based Reasoning: Worms in Contemporary Biomedical Science”, presented at the Workshop on Model Systems, Cases, and Exemplary Narratives in Science and History, Program in the History of Science, Princeton University [October 2] (available on request from the author).Google Scholar
Ankeny, Rachel A. (2000), “Fashioning Descriptive Models in Biology: Of Worms and Wiring Diagrams”, Philosophy of Science 67 (Proceedings): S260–S272.CrossRefGoogle Scholar
Aronson, Jerrold L., Harré, Rom, and Way, Eileen C. (1995), Realism Rescued: How Scientific Progress is Possible. Chicago: Open Court.Google Scholar
Bernard, Claude ([1865] 1957), An Introduction to the Study of Experimental Medicine. Translated by Henry Copley Green. New York: Dover Press.Google Scholar
Blattner, Frederick R. et al. (1997), “The Complete Genome Sequence of Escherichia coli K-12”, Science 277:1453–1462.CrossRefGoogle ScholarPubMed
Bolker, Jessica A. (1995), “Model Systems in Developmental Biology”, BioEssays 17:451–455.CrossRefGoogle ScholarPubMed
Burian, Richard M. (1993), “How the Choice of Experimental Organism Matters: Epistemological Reflections on an Aspect of Biological Practice”, Journal of the History of Biology 26:351–367.CrossRefGoogle Scholar
C. elegans Sequencing Consortium (1998), “Genome Sequence of the Nematode C. elegans: A Platform for Investigating Biology”, Science 282:2012–2018.10.1126/science.282.5396.2012CrossRefGoogle Scholar
Cantor, Charles R. (1990), “Orchestrating the Human Genome Project”, Science 248:49–51.CrossRefGoogle ScholarPubMed
Churchill, Frederick B. (1997), “Life Before Model Systems: General Zoology at August Weismann's Institute”, American Zoologist 37:260–268.CrossRefGoogle Scholar
Clarke, Adele E. and Fujimura, Joan (1992), “What Tools? Which Jobs? Why Right?”, in Clarke, Adele E. and Fujimura, Joan (eds.), The Right Tools for the Job: At Work in Twentieth-Century Life Sciences. Princeton: Princeton University Press, 3–44.CrossRefGoogle Scholar
Clause, Bonnie (1993), “The Wistar Rat as a Right Choice: Establishing Mammalian Standards and the Ideal of a Standardized Mammal”, Journal of the History of Biology 26:329–349.CrossRefGoogle ScholarPubMed
Collins, Francis and Galas, D. (1993), “A New Five-Year Plan for the U.S. Human Genome Project”, Science 262:43–46.CrossRefGoogle ScholarPubMed
Collins, Francis S. et al. (1998), “New Goals for the U.S. Human Genome Project: 1998–2003”, Science 282:682–689.CrossRefGoogle ScholarPubMed
de Chadarevian, Soraya (1998), “Of Worms and Programmes: Caenorhabditis elegans and the Study of Development”, Studies in the History and Philosophy of Science 29:81–105.CrossRefGoogle Scholar
Franklin, Allan (1986), The Neglect of Experiment. Cambridge: Cambridge University Press, 1986.CrossRefGoogle Scholar
Gest, Howard (1995), “Arabidopsis to Zebrafish: A Commentary on ‘Rosetta Stone’ Model Systems in the Biological Sciences”, Perspectives in Biology and Medicine 39:77–85.CrossRefGoogle Scholar
GISC (The Genome International Sequencing Consortium) (2001), “Initial Sequencing and Analysis of the Human Genome”, Nature 409:860–921.CrossRefGoogle Scholar
Goffeau, Andre et al. (1996), “Life with 6000 Genes”, Science 274:546–567.10.1126/science.274.5287.546CrossRefGoogle ScholarPubMed
Hacking, Ian (1983), Representing and Intervening: Introductory Topics in the Philosophy of Natural Science. Cambridge: Cambridge University Press.CrossRefGoogle Scholar
Hesse, Mary B. (1963), Models and Analogies in Science. London: Sheed and Ward.Google Scholar
Holmes, Frederick L. (1993), “The Old Martyr of Science: The Frog in Experimental Physiology”, Journal of the History of Biology 26:311–328.CrossRefGoogle ScholarPubMed
Hughes, C. L. and Kaufman, Thomas C. (2000), “A Diverse Approach to Arthropod Development”, Evolution and Development 2:6–8.CrossRefGoogle ScholarPubMed
Kellogg, E. A. and Shaffer, H. B. (1993), “Model Organisms in Evolutionary Studies”, Systematic Biology 42:409–414.CrossRefGoogle Scholar
Kohler, Robert E. (1991), “Systems of Production: Drosophila, Neurospora, and Biochemical Genetics”, Historical Studies in the Physical and Biological Sciences 22:87–130.CrossRefGoogle Scholar
Kohler, Robert E. (1994), Lords of the Fly: Drosophila Genetics and the Experimental Life. Chicago: University of Chicago Press.Google Scholar
Koshland, Daniel E. (1988), “Biological Systems (Editorial)”, Science 240: 1385.CrossRefGoogle Scholar
LaFollette, Hugh and Shanks, Niall (1996), Brute Science: Dilemmas of Animal Experimentation. London: Routledge.Google Scholar
Mitman, Gregg and Fausto-Sterling, Anne (1992), “Whatever Happened to Planaria? C. M. Child and the Physiology of Inheritance”, in Clarke, Adele E. and Fujimura, Joan (eds.), The Right Tools for the Job: At Work in Twentieth-Century Life Sciences. Princeton: Princeton University Press, 172–196.CrossRefGoogle Scholar
Pennisi, Elizabeth (2000a), “Mouse Sequencers Take Up the Shotgun”, Science 287:1179–1181.CrossRefGoogle Scholar
Pennisi, Elizabeth (2000b), “Fruit Fly Genome Yields Data and a Validation”, Science 287: 1374.Google Scholar
Rader, Karen A. (1998), “‘The Mouse People’: Murine Genetics Work at the Bussey Institution, 1909–1936”, Journal of the History of Biology 31:327–354.CrossRefGoogle Scholar
Pennisi, Elizabeth (1999), “Of Mice, Medicine, and Genetics: C. C. Little's Creation of the Inbred Laboratory Mouse, 1909–1917”, Studies in the History and Philosophy of Biological and Biomedical Sciences 30:319–343.Google Scholar
Schaffner, Kenneth F. (1986), “Exemplar Reasoning about Biological Models and Diseases: A Relation between the Philosophy of Medicine and Philosophy of Science”, Journal of Medicine and Philosophy 11:63–80.CrossRefGoogle Scholar
Schaffner, Kenneth F. (1993), Discovery and Explanation in Biology and Medicine. Chicago: University of Chicago Press.Google Scholar
Schaffner, Kenneth F. (1998), “Model Organisms and Behavioral Genetics: A Rejoinder”, Philosophy of Science 65:276–288.CrossRefGoogle Scholar
Shrader-Frechette, Kristen S. and McCoy, Earl D. (1994), Method in Ecology: Strategies for Conservation. Cambridge: Cambridge University Press.Google Scholar
Sidow, Arend and Thomas, W. Kelley (1994), “A Molecular Evolutionary Framework for Eukaryotic Model Organisms”, Current Biology 4:596–603.CrossRefGoogle ScholarPubMed
U.S. Department of Health and Human Services and U.S. Department of Energy (DHHS/DOE) (1990), Understanding Our Genetic Inheritance. The U.S. Human Genome Project: The First Five Years FY 1991–1995. Washington, DC: GPO.Google Scholar
Venter, J. Craig et al. (2001), “The Sequence of the Human Genome”, Science 291 (5507): 1304–1351.CrossRefGoogle ScholarPubMed
Zallen, Doris (1993), “The ‘Light’ Organism for the Job: Green Algae and Photosynthesis Research”, Journal of the History of Biology 26:269–279.CrossRefGoogle ScholarPubMed