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Identification of Ras, MAP kinases, and a GAP protein in Schistosoma mansoni by immunoblotting and their putative involvement in male–female interaction

Published online by Cambridge University Press:  01 December 1997

P. SCHÜßLER ,
C. G. GREVELDING  and
W. KUNZ
P. SCHÜßLER
Affiliation:
Institut für Genetik, Genetische Parasitologie und Biologisch–Medizinisches Forschungszentrum, Heinrich-Heine-Universität, Universitätsstraße 1, D-40225 Düsseldorf, Germany
C. G. GREVELDING
Affiliation:
Institut für Genetik, Genetische Parasitologie und Biologisch–Medizinisches Forschungszentrum, Heinrich-Heine-Universität, Universitätsstraße 1, D-40225 Düsseldorf, Germany
W. KUNZ
Affiliation:
Institut für Genetik, Genetische Parasitologie und Biologisch–Medizinisches Forschungszentrum, Heinrich-Heine-Universität, Universitätsstraße 1, D-40225 Düsseldorf, Germany
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Abstract

The maturation of female Schistosoma mansoni depends on pairing with a male which induces mitotic activities in the reproductive organs of the female worm. Since in other organisms cell proliferation is regulated by well-conserved signal transducing molecules, we looked for such molecules on immunoblots of schistosomes, using antibodies against conserved epitopes of Ras, GAP and MAP kinases. We identified all 3 molecules in schistosomes and found that they are developmentally regulated. Furthermore, there is evidence for their involvement in the male-directed maturation of the female.

Keywords

Schistosoma mansonisignal transductionRasGAPMAP kinasemale–female interactionpairing-dependent gene expression
Type
Research Article
Information
Parasitology , Volume 115 , Issue 6 , December 1997 , pp. 629 - 634
Copyright
1997 Cambridge University Press

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