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Cardiac and oxidative stress biomarkers in Trypanosoma evansi infected camels: diagnostic and prognostic prominence

Published online by Cambridge University Press:  12 January 2015

W. M. EL-DEEB  and
A. M. ELMOSLEMANY
W. M. EL-DEEB*
Affiliation:
Department of Clinical studies, College of Veterinary Medicine and Animal Resources, King Faisal University, Al-Ahsa, Saudi Arabia Department of Veterinary Medicine, Infectious diseases and fish diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt
A. M. ELMOSLEMANY
Affiliation:
Department of Clinical studies, College of Veterinary Medicine and Animal Resources, King Faisal University, Al-Ahsa, Saudi Arabia Hygiene and Preventive Medicine Department, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafr el-Sheikh 35516, Egypt
*
* Corresponding author. Department of Clinical studies, College of Veterinary Medicine and Animal Resources, King Faisal University, Al-Ahsa, Saudi Arabia. E-mail: weldeeb@kfu.edu.sa, drwaeleldeeb@yahoo.com
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Summary

This study was conducted to investigate the level of cardiac and oxidative stress markers in camels infected with Trypanosoma evansi and to explore the diagnostic and prognostic value of cardiac troponin I (cTnI) and creatine kinase-myocardial band (CK-MB) in response to infection. Seventy four dromedary camels with clinical and laboratory evidence of trypanosomosis and 20 healthy controls were included in this study. Serum cTnI, CK-MB, CK, malondialdehyde (MDA) and super oxide dismutase (SOD) were measured. The values of cTnI, CK-MB, CK and MDA were significantly higher, whereas SOD level was lower in T. evansi infected camel. Successfully treated camels (n = 43) had lower levels of cTnI, CK-MB, CK and MDA, but higher level of SOD compared to camels with treatment failure. Both cTnI and CK-MB showed high degree of accuracy in predicting treatment outcome (success vs failure). The area under the curve for cTnI and CK-MB was 0·98 and 0·93, respectively. However, cTnI showed better sensitivity and specificity than CK-MB (Se = 96·8% vs 83·9% and Sp = 100% vs 88·5%, respectively). These results suggest that cTnI and CK-MB could be used as diagnostic and prognostic biomarkers in camels infected with T. evansi.

Keywords

camelsTrypanosoma evansicardiac troponin Icreatine kinase-MBoxidative stress
Type
Research Article
Information
Parasitology , Volume 142 , Issue 6 , May 2015 , pp. 767 - 772
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Copyright
Copyright © Cambridge University Press 2015 

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