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Regulation of macrophage-mediated larvicidal activity in Echinococcus granulosus and Mesocestoides corti (Cestoda) infection in mice

Published online by Cambridge University Press:  06 April 2009

P. Jenkins ,
J. B. Dixon ,
N. K. Rakha  and
S. D. Carter
P. Jenkins
Affiliation:
Departments of Veterinary Pathology
J. B. Dixon
Affiliation:
Departments of Veterinary Pathology
N. K. Rakha
Affiliation:
Departments of Veterinary Pathology
S. D. Carter
Affiliation:
Departments of Veterinary Pathology Veterinary Clinical Science, University of Liverpool, P.O. Box 147, Liverpool L69 3BX
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Summary

Killing of metacestodes by normal or post-infection macrophages and the regulation of this activity by cytokines were studied in vitro. The protoscolecidal activity of normal macrophages against Echinococcus granulosus was inhibited by a product of naive T-enriched lymphocytes co-cultured with protoscoleces (PSC). By contrast, supernates from co-cultures of Mesocestoides corti tetrathyridia (MCT) and T-enriched or B-enriched normal lymphocytes increased killing of MCT by normal macrophages. Larvicidal activity (against both PSC and MCT) was enhanced by high concentrations of macrophage-activating factors produced by Con A-stimulated rat lymphocytes (Con A-LK), but was reduced by low concentrations of these factors.

Keywords

Echinococcus granulosusMesocestoides corticestodemacrophagecytokine
Type
Research Article
Information
Parasitology , Volume 100 , Issue 2 , April 1990 , pp. 309 - 315
Copyright
Copyright © Cambridge University Press 1990

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