Skip to main content Accessibility help
×
Home
Hostname: page-component-747cfc64b6-ngm8v Total loading time: 0.322 Render date: 2021-06-17T02:42:46.015Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true }

Article contents

The development and validation of an age-structured model for the evaluation of disease control strategies for intestinal helminths

Published online by Cambridge University Press:  06 April 2009

M. S. Chan
Affiliation:
WHO Collaborating Centre for the Epidemiology of Intestinal Parasitic Infections, Department of Biology, ImperialCollege, London SW7 2BB, UK
H. L. Guyatt
Affiliation:
Swiss Tropical Institute, Socinstrasse 57, CH 4002 Basel, Switzerland
D. A. P. Bundy
Affiliation:
WHO Collaborating Centre for the Epidemiology of Intestinal Parasitic Infections, Department of Biology, ImperialCollege, London SW7 2BB, UK
G. F. Medley
Affiliation:
Analysis and Management Group, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK

Summary

Epidemiological modelling can be a useful tool for the evaluation of parasite control strategies. An age-structured epidemiological model of intestinal helminth dynamics is developed. This model includes the explicit representation of changing worm distributions between hosts as a result of treatment, and estimates the morbidity due to heavy infections. The model is used to evaluate the effectiveness of different programmes of age-targeted community chemotherapy in reducing the amount of morbidity due to helminth infection. The magnitude of age-related heterogeneities is found to be very important in determining the results of age-targeted treatment programmes. The model was verified using field data from control programmes for Ascaris lumbricoides and Trichuris trichiura, and was found to provide accurate predictions of prevalence and mean intensities of infection during and following different control regimes.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1994

Access options

Get access to the full version of this content by using one of the access options below.

References

Anderson, R. M. (1980). The dynamics and control of direct life-cycle helminth parasites. Lecture Notes in Biomathematics 39, 278322.CrossRefGoogle Scholar
Anderson, R. M. & May, R. M. (1985). Helminth infections of humans: mathematical models, population dynamics and control. Advances in Parasitology 24, 1101.CrossRefGoogle ScholarPubMed
Anderson, R. M. & May, R. M. (1991). Infectious Diseases of Humans: Dynamics and Control. Oxford: Oxford University Press.Google Scholar
Anderson, R. M. & Medley, G. F. (1985). Community control of helminth infections of man by mass and selective chemotherapy. Parasitology 90, 629–60.CrossRefGoogle Scholar
Bundy, D. A. P. (1988). Population ecology of intestinal helminth infections in human communities. Philosophical Transactions of the Royal Society of London B 321, 405–20.CrossRefGoogle ScholarPubMed
Bundy, D. A. P. (1990). Is the hookworm just another geohelminth? In Hookworm Disease, Current Status and New Directions, (ed. Schad, G. A. & Warren, K. S.), pp. 147–64. London: Taylor & Francis.Google Scholar
Bundy, D. A. P. & Cooper, E. S. (1989). Trichuris and trichuriasis in humans. Advances in Parasitology 28, 107–73.CrossRefGoogle ScholarPubMed
Bundy, D. A. P. & Medley, G. F. (1992). Immuno-epidemiology of human geohelminthiasis: ecological and immunological determinants of worm burden. Parasitology 104, S105–S119.CrossRefGoogle ScholarPubMed
Bundy, D. A. P., Wong, M. S., Lewis, L. L. & Horton, J. (1990). Control of geohelminths by delivery of targeted chemotherapy through schools. Transactions of the Royal Society of Tropical Medicine and Hygiene 84, 115–20.CrossRefGoogle ScholarPubMed
Chan, M. S., Medley, C. F., Jamison, D. & Bundy, D. A. P. (1994). The evaluation of potential global morbidity attributable to intestinal nematode infections. Parasitology 109, 373–87.CrossRefGoogle ScholarPubMed
Cheesmond, A. K. & Fenwick, A. (1981). Human excretion behaviour in a schistosomiasis endemic area of the Gezira, Sudan. Journal of Tropical Medicine and Hygiene 84, 101–7.Google Scholar
Cooper, E. S., Bundy, D. A. P. & Henry, F. J. (1986). Chronic dysentery, stunting, and whipworm infestation. Lancet ii, 280–1.Google Scholar
Cooper, E. S., Bundy, D. A. P., Macdonald, T. T. & Golden, M. H. N. (1990). Growth suppression in the Trichuris dysentery syndrome. European Journal of Clinical Nutrition 44, 285–91.Google ScholarPubMed
Farooq, M. & Mallah, M. B. (1966). The behavioural pattern of social and religious water contact activities in the Egypt 49 bilharziasis project area. Bulletin of the World Health Organization 35, 377–87.Google ScholarPubMed
Guyatt, H. L. (1992). Parasite population biology and the design and evaluation of helminth control programmes. Ph.D. thesis, University of London.Google Scholar
Guyatt, H. L. & Bundy, D. A. P. (1993). Estimation of intestinal nematode prevalence: influence of parasite mating patterns. Parasitology 107, 99106.CrossRefGoogle ScholarPubMed
Guyatt, H. L., Bundy, B. A. P., Medley, G. F. & Grenfell, B. T. (1990). The relationship between the frequency distribution of Ascaris lumbricoides and the prevalence and intensity of infection in human communities. Parasitology 101, 139–43.CrossRefGoogle ScholarPubMed
Guyatt, H. L., Bundy, D. A. P. & Evans, D. (1993). A population dynamic approach to the cost-effectiveness analysis of community-based anthelmintic treatment: Effects of treatment frequency. Transactions of the Royal Society of Tropical Medicine and Hygiene (in the Press).CrossRefGoogle Scholar
Habbema, J. D. F., Alley, E. S., Plaisier, A. P., Van Oortmarssen, G. J. & Remme, J. H. F. (1992). Epidemiological modelling for onchocerciasis control. Parasitology Today 8, 99103.CrossRefGoogle ScholarPubMed
Medley, G. F., Guyatt, H. L. & Bundy, D. A. P. (1993). A quantitative framework for evaluating the effect of community treatment on the morbidity due to ascariasis. Parasitology 106, 211–21.CrossRefGoogle ScholarPubMed
Nokes, C., Grantham-McGregor, S. M., Sawyer, A. W., Cooper, E. S. & Bundy, D. A. p (1992). Parasitic helminth infection and cognitive function in school children. Proceedings of the Royal Society of London B 247, 7781.CrossRefGoogle ScholarPubMed
Plaisier, A. P., Van Oortmarssen, G. J., Habbema, J. D. F., Remme, J. & Alley, E. S. (1990). ONCHOSIM: A model and computer simulation program for the transmission and control of onchocerciasis. Computer Methods and Programs in Biomedicine 31, 4356.CrossRefGoogle ScholarPubMed
Savioli, L., Bundy, D. A. P. & Tomkins, A. M. (1992). Intestinal parasitic infections: a soluble public health problem. Transactions of the Royal Society of Tropical Medicine and Hygiene 86, 353–4.CrossRefGoogle ScholarPubMed
Stephenson, L. S., Latham, M. C., Kurz, K. M., Kinoti, S. N. & Brigham, H. (1989). Treatment with a single dose of albendazole improves growth of Kenyan schoolchildren with hookworm, Trichuris trichiura and Ascaris lumbricoides infections. American Journal of Tropical Medicine and Hygiene 41, 7887.CrossRefGoogle ScholarPubMed
Stephenson, L. S., Latham, M. C., Kinoti, S. N., Kurz, K. M. & Brigham, H. (1990). Improvements in physical fitness of Kenyan schoolboys infected with hookworm, Trichuris trichiura and Ascaris lumbricoides following a single dose of albendazole. Transactions of the Royal Society of Tropical Medicine and Hygiene 84, 277–82.CrossRefGoogle ScholarPubMed
Thein, Hlaing, Than-Saw, & Myat-Lay-Kyin, (1991). The impact of three monthly age-targeted chemotherapy on Ascaris lumbricoides infection. Transactions of the Royal Society of Tropical Medicine and Hygiene 85, 519&22.CrossRefGoogle Scholar
Warren, K. S., Bundy, D. A. P., Anderson, R. M., Davis, A. R., Henderson, D. A., Jamison, B. T., Prescott, N. & Senft, A. (1993). Helminth infections. In Disease Control Priorities in Developing Countries, (ed. Jamison, D. T., Mosley, W. H., Measham, A. R. & Bobadilla, J. L.), pp. 131160. Oxford: Oxford University Press.Google Scholar
World Health Organization (1987). Prevention and Control of Intestinal Parasitic Infections. WHO Technical Report Series No. 749. Geneva.Google Scholar
World Health Organization (1993). Epidemiological modelling for schistosomiasis control. American Journal of Tropical Medicine and Hygiene (in the Press).Google Scholar
Woolhouse, M. E. J. (1991). On the application of mathematical models of schistosome dynamics. 1. Natural transmission. Acta tropica 49, 241–70.CrossRefGoogle Scholar
Yokogawa, M. (1985). JOICFP's experience in the control of ascariasis within an integrated programme. In Ascariasis and its Public Health Significance, (ed. Crompton, D. W. T., Nesheim, M. C. & Pawlowski, Z. S.), pp. 265–78. London: Taylor & Francis.Google Scholar
43
Cited by

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

The development and validation of an age-structured model for the evaluation of disease control strategies for intestinal helminths
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

The development and validation of an age-structured model for the evaluation of disease control strategies for intestinal helminths
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

The development and validation of an age-structured model for the evaluation of disease control strategies for intestinal helminths
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *