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Validity and reliability of the Turkish version of the functional assessment of cancer therapy–bone marrow transplant (FACT-BMT) quality of life questionnaire in patients undergoing bone marrow transplantation

Published online by Cambridge University Press:  22 July 2021

Vesile Yildiz Kabak Open the ORCID record for Vesile Yildiz Kabak [Opens in a new window] ,
Arzu Demircioglu ,
Elifcan Aladag ,
Sevilay Karahan ,
Hakan Goker ,
Songul Atasavun Uysal  and
Tulin Duger
Vesile Yildiz Kabak*
Affiliation:
Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey
Arzu Demircioglu
Affiliation:
Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey
Elifcan Aladag
Affiliation:
Department of Hematology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Sevilay Karahan
Affiliation:
Department of Biostatistics, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Hakan Goker
Affiliation:
Department of Hematology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Songul Atasavun Uysal
Affiliation:
Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey
Tulin Duger
Affiliation:
Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey
*
Author for correspondence: Vesile Yildiz Kabak, Hacettepe University, Faculty of Physical Therapy and Rehabilitation, Sıhhiye, 06100Ankara, Turkey. E-mail: vesile_yldz@hotmail.com
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Abstract

Objective

The Functional Assessment of Cancer Therapy–Bone Marrow Transplant Version 4 (FACT-BMT) is a widely used instrument to assess quality of life in individuals treated with bone marrow transplantation (BMT). Our aim was to determine the reliability and validity of the Turkish version of the FACT-BMT in patients undergoing BMT.

Method

Patients between the age of 20 and 65 years and who had undergone BMT at least 3 months before the study were included. Validity was determined using exploratory and confirmatory factor analysis. To determine convergent validity, the European Cancer Research and Treatment Organization Quality of Life Questionnaire–Cancer30 (EORTC QLQ-C30), the Brief Fatigue Inventory (BFI), and the Eastern Cooperative Oncology Group (ECOG) performance score were used. Cronbach's alpha, intra-class correlation coefficient (ICC), and item-total correlation (ITC) values were calculated to assess the reliability of the FACT-BMT.

Results

Totally, 114 patients (F/M: 47/67) treated with BMT (mean age: 49.50 ± 12.50 years) were included. Confirmatory and exploratory factor analysis revealed that the FACT-BMT and the Bone Marrow Transplantation Subscale (BMTS) had sufficient fit. The FACT-BMT was moderately to strongly correlated with the EORTC QLQ-C30, the BFI, and the ECOG performance score (p < 0.001). Cronbach's alpha and ICC values of the FACT-BMT were acceptable (0.925 and 0.956, respectively). The ITC values of each item of the FACT-BMT were also acceptable (ranged from 0.296 to 0.737). Patients undergoing autologous BMT had a significantly higher BMTS score than those undergoing allogeneic BMT (p < 0.05).

Significance of results

The Turkish version of the FACT-BMT is valid, reliable, and sensitive to changes in quality of life in patients undergoing BMT.

Keywords

Bone marrow transplantationQuality of lifeQuestionnaireReliability and validity
Type
Original Article
Information
Palliative & Supportive Care , Volume 20 , Issue 4 , August 2022 , pp. 556 - 563
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Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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