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Diet and haemostatic processes

Published online by Cambridge University Press:  14 December 2007

Hester H. Vorster ,
John H. Cummings  and
Johann C. Jerling
Hester H. Vorster
Affiliation:
Department of Nutrition, Potchefstroom University for Christian Higher Education, Potchefstroom, 2520, South Africa
John H. Cummings
Affiliation:
MRC Dunn Clinical Nutrition Centre, Cambridge, CB2 2DH, UK.
Johann C. Jerling
Affiliation:
Department of Nutrition, Potchefstroom University for Christian Higher Education, Potchefstroom, 2520, South Africa
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Abstract

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Diet plays an important role in the primary and secondary prevention of cardiovascular disease. The growing perception that abnormal haemostatic processes of coagulation, platelet aggregation and fibrinolysis contribute to cardiovascular disease aetiology motivated this review on the relationships of diet, specific foods and nutrients with haemostatic function. Functional endpoints that reflect the function and status of some of these processes and which can be measured in dietary trials are identified. The effects of energy intake and expenditure, alcohol, total fat and specific fatty acids, non-starch polysaccharides (dietary fibre), antioxidant nutrients and some foods on a variety of haemostatic markers are reviewed. The results indicate that the prudent low-fat, high-fibre diet and maintenance of ideal body weight recommended to protect against and treat hyperlipidaemia and coronary heart disease will also benefit haemostatic profiles. It is concluded that more research on specific effects is needed for improved recommendations on a population level for prevention of cardiovascular disease.

Type
Research Article
Information
Nutrition Research Reviews , Volume 10 , Issue 1 , January 1997 , pp. 115 - 135
Copyright
Copyright © The Nutrition Society 1997

References

Ali, M. & Afzal, M. (1987). A potent inhibitor of thrombin stimulated platelet thromboxane formation from unprocessed tea. Prostaglandins, Leukotrienes and Medicine 27. 9–13.CrossRefGoogle ScholarPubMed
Altomare, D. F., Semeraro, N. & Colucci, M. (1993). Reduction of the plasma levels of tissue plasminogen activator after infusion of a lipid emulsion in humans. Journal of Parenteral and Enteral Nutrition 17, 274–276.CrossRefGoogle ScholarPubMed
Assmann, G. & Schulte, H. (1992). The importance of triglycerides: results from the Prospective Cardiovascular Munster (PROCAM) Study. European Journal of Epidemiology 8 (Suppl. 1). 99–103.CrossRefGoogle ScholarPubMed
Avellone, G., Di Garbo, V., Cordova, R., Raneli, G., De Simone, R. & Bompiani, G. D. (1994). Coagulation, fibrinolysis and haemorheology in premenopausal obese women with different body fat distribution. Thrombosis Research 75, 223–231.CrossRefGoogle ScholarPubMed
Aznar, J. & Estelles, A. (1994) Role of plasminogen activator inhibitor type 1 in the pathogenesis of coronary artery diseases. Haemostasis 24, 243–251.Google ScholarPubMed
Basista, M. H., Joseph, A., Smolen, S., Koterba, A. & Brecher, A. S. (1994). Acetaldehyde alters coagulation protein function. Digestive Diseases and Sciences 39, 2421–2425.CrossRefGoogle ScholarPubMed
Bertina, R. M., Van Tilburg, N. H., De Fouw, N. J. & Haverkate, F. (1992). Thrombin, a link between coagulation activation and fibrinolysis. Annals of the New York Academy of Sciences 667, 239–248.CrossRefGoogle ScholarPubMed
Bladbjerg, E. M., Marckmann, P., Sandström, B. & Jespersen, J. (1994). Non-fasting factor VII coagulant activity (F VII:C) increased by high-fat diet. Thrombosis and Haemostasis 71, 755–758.Google Scholar
Bladbjerg, E. M., Tholstrup, T., Marckmann, P., Sandström, B. & Jespersen, J. (1995). Dietary changes in fasting levels of factor VII coagulant activity (F VII:C) are accompanied by changes in factor VII protein and other vitamin K-dependent proteins. Thrombosis and Haemostasis 73, 239–242.Google Scholar
Boberg, M., Pollare, T., Siegbahn, A. & Vessby, B. (1992). Supplementation with n-3 fatty acids reduces triglycerides but increases PAI-I in non-insulin-dependent diabetes mellitus. European Journal of Clinical Invesrigation 22, 645–650.CrossRefGoogle Scholar
Boman, K., Hellsten, G., Bruce, A., Hallmans, G. & Nilsson, T. K. (1994). Endurance physical activity, diet and fibrinolysis. Arherosclerosis 106, 65–74.CrossRefGoogle ScholarPubMed
Brown, A. J. & Roberts, D. C. K. (1991). Fish and fish oil intake: effect on haematological variables related to cardiovascular disease. Thrombosis Research 64, 169–178.CrossRefGoogle ScholarPubMed
Calles-Escandon, J., Ballor, D., Harvey-Berino, J., Ades, P. & Tracy, R. (1996). Amelioration of the inhibition of fibrinolysis in elderly, obese subjects by moderate energy intake restriction. American Journal of Clinical Nutrition 64, 7–11.CrossRefGoogle ScholarPubMed
Carr, M. E. & Alving, B. M. (1995). Effect of fibrin structure on plasmin-mediated dissolution of plasma clots. Blood Coagulation and Fibrinolysis 6, 567–573.CrossRefGoogle ScholarPubMed
Cepelak, V., Dvorak, J., Vit, L., Cepelakova, H. & Beranek, V. (1991). Disorders of fibrinolysis and thrombophilic states, risk factors and possibilities of dietary effects. Vnitrni Lekarstvi 37, 13–20.Google ScholarPubMed
Challen, A. D., Branch, W. J. & Cummings, J. H. (1983). The effect of pectin and wheat bran on platelet function and haemostasis in man. Human Nurrition: Clinical Nutrition 37C, 209–217.Google Scholar
Chen, H. W., Hendrich, S. & Cook, L. R. (1994). Vitamin E deficiency increases serum thromboxane A2. platelet arachidonate and lipid peroxidation in male Sprague-Dawley rats. Prostaglandins Leukotrienes and Essential Fatty Acids 51, 11–17.CrossRefGoogle ScholarPubMed
Collet, J. P., Soria, J., Mirshahi, M., Hirsch, M., Dagonnet, F. B., Caen, J. & Soria, C. (1993). Dusart syndrome: a new concept of the relationship between fibrin clot architecture and fibrin clot degradability: hypofibrinolysis related to an abnormal clot structure. Blood 82, 2462–2469.CrossRefGoogle Scholar
Connelly, J. B., Cooper, J. A. & Meade, T. W. (1992). Strenuous exercise, plasma fibrinogen, and factor VII activity. British Heart Journal 67, 351–354; 68, 160.CrossRefGoogle ScholarPubMed
Daae, L. N. W., Kierulf, P., Landaas, S. & Urdal, P. (1993). Cardiovascular risk factors: interactive effects of lipids, coagulation and fibrinolysis. Scandinavian Journal of Clinical and Loboratory Investigation 53 (Suppl. 215). 19–27.CrossRefGoogle Scholar
Dittman, W. A. & Majerus, P. W. (1990). Structure and function of thrombomodulin: a natural anticoagulant. Blood 75, 329–336.CrossRefGoogle ScholarPubMed
Doll, R., Peto, R., Hall, E., Wheatley, K. & Gray, R. (1994). Mortality in relation to consumption of alcohol: 13 years' observations on male British doctors. British Medical Journal, 309, 911–918.CrossRefGoogle ScholarPubMed
Dupont, J., Holub, B. J., Knapp, H. R. & Meydani, M. (1996). Fatty acid-related functions. American Journal of Clinical Nutrition 63, 9915–9935.CrossRefGoogle ScholarPubMed
Dyerberg, J. (1986). Linolenate-derived polyunsaturated fatty acids and prevention of atherosclerosis. Nutrition Reviews 44, 125–134.CrossRefGoogle ScholarPubMed
El-Sayed, M. S. & Davies, B. (1995). A physical conditioning program does not alter fibrinogen concentration in young healthy subjects. Medicine and Science in Sports and Exercise 27, 485–489.CrossRefGoogle Scholar
Eliasson, M., Asplund, K., Evrin, P. E., Huhtasaari, F. & Johansson, I. (1995). Plasma fibrinogen, fibrinolysis and (pro) vitamins; Is there a connection? Fibrinolysis 9, 87–92.CrossRefGoogle Scholar
Eritsland, J., Amesen, H., Seljetlot, I. & Kierulf, P. (1995). Long-term effects of n-3 polyunsaturated fatty acids on haemostatic variables and bleeding episodes in patients with coronary artery disease. Blood Coagulation and Fibrinolysis 6, 17–22.CrossRefGoogle ScholarPubMed
Esmon, C. T. (1993). Cell mediated events that control blood coagulation and vascular injury. Annual Review of Cell Biology 9, 1–26.CrossRefGoogle ScholarPubMed
Fanari, P., Somazzi, R., Nasrawi, F., Ticozzelli, P., Grugni, G., Agosti, R. & Longhini, E. (1993) Haemorheological changes in obese adolescents after short-term diet. International Journal of Obesiry and Related Metabolic Disorders 17, 487–494.Google ScholarPubMed
Fatah, K., Hamsten, A., Blomback, B. & Blomback, M. (1992) Fibrin gel network characteristics and coronary heart disease: relations to plasma fibrinogen concentration, acute phase protein, serum lipoproteins and coronary atherosclerosis. Thrombosis and Haemostasis 68, 130–135.Google ScholarPubMed
Fehily, A. M., Burr, M. L., Butland, B. K. & Eastham, R. D. (1986). A randomized controlled trial to investigate the effect of a high fibre diet on blood pressure and plasma fibrinogen. Journal of Epidemiology and Community Health 40, 334–337.CrossRefGoogle ScholarPubMed
Fehily, A. M., Milbank, J. E., Yamell, J. W. G., Hayes, T. M., Kubiki, A. J. & Eastham, R. D. (1982) Dietary determinants of lipoproteins, total cholesterol, viscosity, fibrinogen. and blood pressure. American Journal of Clinical Nutrition 36, 890–896.CrossRefGoogle ScholarPubMed
Ferlito, S. & Di Mauro, C. (1990) Effects of an oral fat load on some prothrombotic markers in coronary heart patients. Panminema Medica 32, 101–104.Google ScholarPubMed
Folsom, A. R., Qamhieh, H. T., Wing, R. R., Jeffery, R. W., Stinson, V. L., Kuller, L. H. & Wu, K. K. (1993) Impact of weight loss on plasminogen activator inhibitor (PAI-I), factor VII, and other hemostatic factors in moderately overweight adults. Arteriosclerosis and Thrombosis 13, 162–169.CrossRefGoogle Scholar
Folsom, A. R., Wu, K. K., Davis, C. E., Conlan, M. G., Sorlie, P. D. & Szklo, M. (1991). Population correlates of plasma fibrinogen and factor VII, putative cardiovascular risk factors. Afherosclerosis 91, 191–205.CrossRefGoogle ScholarPubMed
Freese, R. & Mutanen, M. (1995) Postprandial changes in platelet function and coagulation factors after high-fat meals with different fatty acid compositions. European Journal of Clinical Nutririon 49, 658–464.Google ScholarPubMed
Gelmini, G., Coiro, V., Manotti, C., Delsignore, R. & Passeri, M. (1989). Effect of diet and weight loss on whole blood filterability and plasma fibrinogen values in hypertensive obese postmenopausal women. Acta Diabetologia Lotina 26, 329–335.CrossRefGoogle ScholarPubMed
Genest, J. & Cohn, J. S. (1995) Clustering of cardiovascular risk factors: targeting high-risk individuals. American Journal of Cardiology 76, 8A–20A.CrossRefGoogle ScholarPubMed
Glatzel, H. & Rüberg-Schweer, M. (1965) [Nutrition and circulation control. 7. Activation of fibrinolysis by spices (chillies).] Kreislaufforschung 53. 374–384.Google Scholar
Glatzel, H. & Ruberg-Schweer, M. (1967). [Effects of coagulation and fibrinolysis due to common local spices.] Medizinische Klinik 62, 1086–1088.Google Scholar
Guyton, A. C. (1991). Hemostasis and blood coagulation. Textbook of Medical Physiology, 8th edn. pp. 390–399. Philadelphia, PA: W. B. Saunders.Google Scholar
Haglund, O., Luoslarinen, R., Wallin, R., Wibell, I., & Saldeen, T. (1991). The effects of fish oil on triglycerides. cholesterol, fibrinogen and malondialdehyde in humans supplemented with vitamin E. Journal of Nutrition 121, 165–169.CrossRefGoogle ScholarPubMed
Haines, A. P., Chakrabarti, R., Fisher, D., Meade, T. W., North, W. R. S. & Stirling, Y. (1980). Haemostatic variables in vegetarians and non-vegetarians. Thrombosis Research 19, 139–148.CrossRefGoogle ScholarPubMed
Haines, A. P., Sanders, T. A. B., Imeson, J. D., Mahler, R. F., Martin, J., Mistry, M., Vickers, M. & Wallace, P. G. (1986). Effects of a fish oil supplement on platelet function, haemostatic variables and albuminuria in insulin-dependent diabetics. Thrombosis Research 43, 643–655.CrossRefGoogle ScholarPubMed
Hamsten, A. & Erihson, P. (1995). Fibrinolysis and atherosclerosis. Bailliéres Clinical Haematology 8, 345–363.CrossRefGoogle ScholarPubMed
Hankey, C. R., Rumley, A., Ha, T., Lowe, G. D. O. & Lean, M. E. J. (1996). Plasma coagulation, fibrinolysis and (pro)vitamins in those with ischaemic heart disease. Fibrinolysis 10, 193.CrossRefGoogle Scholar
Hendriks, H. F. J., Veenstra, J., Velthuis-te Wierik, E. J. M., Schaafsma, G. & Kluft, C. (1994). Effect of moderate dose of alcohol with evening meal on fibrinolytic factors. British Medical Journal 308, 1003–1006.CrossRefGoogle ScholarPubMed
Herren, T., Stricker, H., Haeberli, A., Do, D, D. & Straub, P. W. (1994). Fibrin formation and degradation in patients with arteriosclerotic disease. Circulation 90. 2679–2686.CrossRefGoogle ScholarPubMed
Herrmann, W., Biermann, J. & Kostner, G. M. (1995). Comparison of effects of n-3 to n-6 fatty acids on serum level of lipoprotein (a) in patients with coronary artery disease. American Journal of Cardiology 76, 459–462.CrossRefGoogle ScholarPubMed
Ho, C. H., Chwang, L. C. & Hwang, B. H. (1995). The influence of high fat diet on the fibrinolytic activity. Thrombosis Research 77, 201–208.CrossRefGoogle ScholarPubMed
Høstmark, A. T., Bjerkedal, T., Kierulf, P., Flaten, H. & Ulshagen, K. (1988). Fish oil and plasma fibrinogen. British Medical Journal 297, 180–181.CrossRefGoogle ScholarPubMed
Howard, B. V., Le, N. A., Bekker, J. D., Flack, J. M., Jacobs, D. R., Lewis, C. E., Macrovina, S. M. & Perkins, L. L. (1994). Concentrations of Lp(a) in black and white young adults: relations to risk factors for cardiovascular disease. Annals of Epidemiology 4, 341–350.CrossRefGoogle ScholarPubMed
Huisveld, I. A., Leenen, R., Van der Kooy, K., Hospers, J. E. H., Seidell, J. C., Deurenberg, P., Koppeschaar, H. P. F., Mosterd, W. L. & Bouma, B. N. (1990). Body composition and weight reduction in relation to antigen and activity of plasminogen activator inhibitor (PAI-I) in overweight individuals. Fibrinolysis 4 (Suppl. 2). 84–85.CrossRefGoogle Scholar
Iso, H., Folsom, A. R., Koike, K. A., Sato, S., Wu, K. K., Shimamoto, T., lida, M. & Komachi, Y. (1993 a). Antigens of tissue plasminogen activator and plasminogen activator inhibitor I: correlates in nonsmoking Japanese and Caucasian men and women. Thrombosis and Hoemostasis 70, 475–480.Google ScholarPubMed
Iso, H., Folsom, A. R., Sato, S., Wu, K. K., Shimamoto, T., Koike, K. A., Iida, M. & Komachi, Y. (1993 b). Plasma fibrinogen and its correlates in Japanese and US population samples. Arteriosclerosis and Thrombosis 13, 783–790.CrossRefGoogle ScholarPubMed
Jerling, J. C., Vorster, H. H., Oosthuizen, W., Silvis, N. & Venter, C. S. (1994). Differences in plasminogen activator inhibitor I activity between blacks and whites may be diet related. Haemostasis 24, 364–368.Google ScholarPubMed
Juhan-Vague, I., Thompson, S. G. & Jespersen, J. (1993). Involvement of the hemostatic system in the insulin resistance syndrome. A study of 1500 patients with angina pectoris. Arteriosclerosis and Thrombosis 13, 1865–1873.CrossRefGoogle ScholarPubMed
Katan, M. B. (1995). Fish and heart disease (editorial). New England Jouml of Medicine 332, 1024–1025.CrossRefGoogle Scholar
Kiserud, C. E., Kierulf, P. & Hostmark, A. T. (1995). Effects of various fatty acids alone or combined with vitamin E on cell growth and fibrinogen concentration in the medium of HepG2 cells. Thrombosis Research 80, 75–83.CrossRefGoogle ScholarPubMed
Koepp, P. & Hegewisch, S. (1981). Effects of guar on plasma viscosity and related parameters in diabetic children. European Journal of Pediatrics 137, 31–33.CrossRefGoogle ScholarPubMed
Kozima, Y., Urano, T., Serizawa, K., Takada, Y. & Takada, A. (1993). Impaired fibrinolytic activity induced by ingestion of butter: effect of increased plasma lipids on the fibrinolytic activity. Thrombosis Research 70, 191–202.CrossRefGoogle ScholarPubMed
Krobot, K., Hense, H. W., Cremer, P., Eberle, E. & Keil, U. (1992). Determinants of plasma fibrinogen: relation to body weight, waist-to-hip ratio, smoking, alcohol, age, and sex. Results from the second MONICA Augsburg survey 1989–1990. Arteriosclerosis and Thrombosis 12, 780–788.CrossRefGoogle ScholarPubMed
Kromhout, D., Bosschieter, E. B. & De Lezenne Coulander, C. (1985). The inverse relation between fish consumption and 20-year mortality from coronary heart disease. New England Journal of Medicine 312, 1205–1209.CrossRefGoogle ScholarPubMed
Kruger, A., Vorster, H. H., Venter, C. S. & Viljoen, M. J. (1994). Increased plasma fibrinogen with age—eugeriatric or pathogeriatric phenomenon? Cardiovascular Journal of Southern Africa 5, 110–116.Google Scholar
Landin, K., Holrn, G., Tengborn, L. & Smith, U. (1992). Guar gum improves insulin sensitivity, blood lipids, blood pressure, and fibrinolysis in healthy men. American Journal of Clinical Nutrition 56, 1061–1065.CrossRefGoogle ScholarPubMed
Lee, A. J., Flanagan, P. A., Rumley, A., Fowkes, F. G. R. & Lowe, G. D. O. (1995). Relationship between alcohol intake and tissue plasminogen activator antigen and other haemostatic factors in the general population. Fibrinolysis 8, 49–54.CrossRefGoogle Scholar
Licata, G., Scaglione, R., Avellone, G., Ganguzza, A., Corrao, B., Arnone, S. & Di Chiara, T. (1995). Hemostatic function in young subjects with central obesity: relationship with left ventricular function. Metabolism 44, 1417–1421.CrossRefGoogle ScholarPubMed
Lipinski, B., Federman, S. M. & Krolewski, A. S. (1995). Macromolecular protein complex of human plasma: interaction with fibrin and fibrinolysis. Thrombosis Research 78, 461–465.CrossRefGoogle ScholarPubMed
Lopez-Segura, F., Velasco, F., Lopez-Miranda, J., Castro, P., Lopez-Pedrera, R., Blanco, A. et al. (1996). Monounsaturated fatty acid-enriched diet decreases plasma plasminogen activator inhibitor type I. Arteriosclerosis. Thrombosis, and Vascular Biology 16, 82–88.CrossRefGoogle Scholar
Marckmann, P. (1995). Diet, blood coagulation and fibrinolysis. Danish Medical Bulletin 42, 410–425.Google ScholarPubMed
Marckmann, P., Sandström, B. & Jespersen, J. (1992). Fasting blood coagulation and fibrinolysis of young adults unchanged by reduction in dietary fat content. Arteriosclerosis and Thrombosis 12, 201–205.CrossRefGoogle ScholarPubMed
Marckmann, P., Sandström, B. & Jespersen, J. (1993). Favorable long-term effect of a low-fat/high-fiber diet on human blood coagulation and fibrinolysis. Arteriosclerosis and Thrombosis 13, 505–511.CrossRefGoogle ScholarPubMed
Marques-Vidal, P., Cambou, J. P., Nicaud, V., Luc, G., Evans, A., Arveiler, D., Bingham, A. & Cambien, F. (1995). Cardiovascular risk factors and alcohol consumption in France and Northern Ireland. Atherosclerosis 115, 225–232.CrossRefGoogle ScholarPubMed
Meade, T. W., Chakrabarti, R., Haines, A. P., North, W. R. S. & Stirling, Y. (1979). Characteristics affecting fibrinolytic activity and plasma fibrinogen concentrations. British Medical Journal i, 153–156.CrossRefGoogle Scholar
Mehrabian, M., Peter, J. B., Barnard, R. J. & Lusis, A. I. (1990). Dietary regulation of fibrinolytic factors. Atherosclerosis 84, 25–32.CrossRefGoogle ScholarPubMed
Mennen, L. I., Schouten, E. G., Grobbee, D. E. & Kluft, C. (1996). Coagulation factor VII. dietary fat and blood lipids: a review. Thrombosis and Haemostasis 76, 492–499.Google ScholarPubMed
Menon, I. S., Kendal, R. Y., Dewar, H. A. & Newell, D. J. (1968). Effect of onions on blood fibrinolytic activity. Brirish Medical Journal iii. 351.CrossRefGoogle Scholar
Merlini, P. A., Bauer, K. A., Oltrona, L., Ardissino, D.Spinola, A., Cattaneo, M., Broccolino, M., Mannucci, P. M. & Rosenberg, R. D. (1995). Thrombin generation and activity during thrombolysis and concomitant heparin therapy in patients with acute myocardial infarction. Journal of the American College of Cardiology 25, 203–209.CrossRefGoogle ScholarPubMed
Mikhailidis, D. P., Barradas, M. A., Maris, A., Jeremy, J. Y. & Dandona, P. (1985). Fibrinogen mediated activation of platelet aggregation and thromboxane A2 release: pathological implications in vascular disease. Joural of Clinical Pathology 38, 1166–1171.CrossRefGoogle ScholarPubMed
Miller, G. J. (1992). Hemostasis and cardiovascular risk. The British and European experience. Archives of Pathology and Laboratory Medicine 116, 1318–1321.Google ScholarPubMed
Miller, G. J. (1993). Hyperlipidaemia and hypercoagulability. Progress in Lipid Research 32, 61–69.CrossRefGoogle ScholarPubMed
Mitropoulos, K. A. (1994). Lipid-thrombosis interface. Brirish Medical Bulletin 50, 813–832.CrossRefGoogle ScholarPubMed
Morris, J. N. (1994). Exercise in the prevention of coronary heart disease: today's best buy in public health. Medicine and Science in Sports and Exercise 26, 807–814.CrossRefGoogle ScholarPubMed
Mundal, H. H., Meltzer, H. M. & Aursnes, I. (1994). Bleeding times related to serum triglyceride levels in healthy young adults. Thrombosis Research 75, 285–291.CrossRefGoogle ScholarPubMed
Mutanen, M., Krusius, T., Rasanen, L., Freese, R., Vahtera, E. & Viikari, J. S. A. (1995). Habitual diet. platelet function, fibrinogen and factor VII coagulant activity in young Finns. Journal of Internal Medicine 237, 577–583.CrossRefGoogle ScholarPubMed
Nadler, J. L., Malayan, S., Luong, H., Shaw, S., Natarajan, R. D. & Rude, R. K. (1992). lntracellular free magnesium deficiency plays a key role in increased platelet reactivity in type II diabetes mellitus. Diabetes Care 15, 835–841.CrossRefGoogle Scholar
Nair, C. H. & Dhall, D. P. (1991). Studies on fibrin network structure: the effect of some plasma proteins. Thrombosis Research 61, 315–325.CrossRefGoogle ScholarPubMed
Nieuwenhuizen, W. (1994). Biochemistq and measurement of fibrinogen. Blood Coagulation and Fibrinolysis 5 (Suppl. 2), 1.Google Scholar
Nilsson, T. K., Sundell, I. B., Hellsten, G. & Hallmans, G. (1990). Reduced plasminogen activator inhibitor activity in high consumers of fruits, vegetables and root vegetables. Journal of Internal Medicine 227, 267–271.CrossRefGoogle ScholarPubMed
Oosthuizen, W., Vorster, H. H., Jerling, J. C., Barnard, H. C., Smuts, C. M., Silvis, N., Kruger, A. & Venter, C. S. (1994). Both fish oil and olive oil lowered plasma fibrinogen in women with high baseline fibrinogen levels. Thrombosis and Haemostasis 72, 557–562.Google ScholarPubMed
Oosthuizen, W., Vorster, H. H., Jerling, J. C., Lessing, M. C., Veldman, F. J., Kruger, A. & Vermaak, W. J. H. (1996). Increased plasma fibrinogen levels in ‘healthy’ obese women. Abstract. XIVth International Fibrinogen Workshop, Canberra, Australia.CrossRefGoogle Scholar
Osterud, B., Elvevoll, E., Barstad, H., Brox, J., Halvorsen, H., Lia, K., Olsen, J. O. et al. (1995). Effect of marine oils supplementation on coagulation and cellular activation in whole blood. Lipids 30, 1111–1118.CrossRefGoogle ScholarPubMed
Packham, M. A. & Mustard, J. F. (1986). The role of platelets in the development and complications of atherosclerosis. Seminars in Hematology 23, 8–26.Google ScholarPubMed
Palareti, G., Legnani, C., Poggi, M., Parenti, M., Babini, A. C., Biagi, R., Baraldi, L., Luchi, A., Capelli, M. & Coccheri, S. (1994). Prolonged very low calorie diet in obese subjects reduces factor VII and PA1 but not fibrinogen levels. Fibrinolysis 8, 16–21.CrossRefGoogle Scholar
Palareti, G., Maccaferri, M., Poggi, M., Legnani, C. & Coccheri, S. (1992). Fibrinogen measurement in various clinical conditions: a comparison of five different methods. In Fibrinogen: a ‘new’ cardiovascular risk factor, pp. 64–67 [Ernst, E.Koenig, W.Lowe, G. D. O. and Meade, T. W., editors]. Oxford: Blackwell.Google Scholar
Pan, W. H., Chin, C. J., Sheu, C. T. & Lee, M. H. (1993). Hemostatic factors and blood lipids in young Buddhist vegetarians and omnivores. American Journal of Clinical Nutrition 58, 354–359.CrossRefGoogle ScholarPubMed
Petemel, P., Stegnar, M., Mavri, A. & Salobir-Pajnic, B. (1994). The effect of fasting and/or body weight reduction on tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI-I). Fibrinolysis 8 (Suppl. 2). 41–43.CrossRefGoogle Scholar
Petroni, A., Blasevich, M., Salami, M., Papini, N., Montedoro, G. F. & Galli, C. (1995). Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil. Thrombosis Research 78, 151–160.CrossRefGoogle ScholarPubMed
Pilgeram, L. O. & Pickart, L. R. (1968). Control of fibrinogen biosynthesis: the role of free fatty acids. Atherosclerosis Research 8, 155–166.CrossRefGoogle Scholar
Poggi, M., Palareti, G., Biagi, R., Legnani, C., Parenti, M., Babini, A. C., Baraldi, L. & Coccheri, S. (1994). Prolonged very low calorie diet in highly obese subjects reduces plasma viscosity and red cell aggregation but not fibrinogen. International Journal of Obesity and Related Metabolic Disorders 18, 490–496.Google Scholar
Rankinen, T., Rauramaa, R., Vaisanen, S., Penttila, I. M. & Uusitupa, M. (1994). Relation of habitual diet and cardiorespiratory fitness to blood coagulation and fibrinolytic factors. Thrombosis and Haemostasis 71. 180–183.Google ScholarPubMed
Rankinen, T., Vaisanen, S., Penttila, I. & Rauramaa, R. (1995). Acute dynamic exercise increase fibrinolytic activity. Thrombosis and Haemostasis 73, 281–286.Google ScholarPubMed
Renaud, S C., Beswick, A. D., Fehily, A. M., Sharp, D. S. & Elwood, P. C. (1992). Alcohol and platelet aggregation: the Caerphilly Prospective Heart Disease Study. American Journal of Clinical Nutrition 55, 1012–1017.CrossRefGoogle ScholarPubMed
Renaud, S. & De Logeril, M. (1992). Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 339, 1523–1526.CrossRefGoogle ScholarPubMed
Renaud, S., Godsey, F., Dumont, E., Thevenon, C., Ortchanian, E. & Martin, J. L., (1986). Influence of long-term diet modification on platelet function and composition in Moselle farmers. American Journal of Clinical Nutrition 43, 136–150.CrossRefGoogle ScholarPubMed
Resch, K. L. & Ernst, E. (1995). [Garlic(Allium sativum)—a potent medicinal plant.] Fortschritte der Medizin 113, 311–315.Google ScholarPubMed
Rosenberg, R. D. & Bauer, K. A. (1992). Does a prethrombotic state exist? If so, what is it? American Journal of Clinical Nutrition 56, 787S–788S.CrossRefGoogle ScholarPubMed
Rubanyi, G. M. (1993). The role of endothelium in cardiovascular homeostasis and diseases. Journal of Cardiovascular Pharmacology 22 (Suppl. 4), S1–S14.CrossRefGoogle ScholarPubMed
Sanders, T. A. & Roshanai, F. (1992). Platelet phospholipid fatty acid composition and function in vegans compared with age- and sex-matched omnivore controls. European Journal of Clinical Nutrition 46, 823–831.Google ScholarPubMed
Schmidt, E. B., Lervang, H. H., Varming, K., Madsen, P. & Dyerberg, J. (1992). Long-term supplementation with n-3 fatty acids. I. Effect on blood lipids, haemostasis and blood pressure. Scandinavian Journal of Clinical and Laboratory Investigation 52, 221–228.CrossRefGoogle ScholarPubMed
Shahar, E., Folsom, A. R., Wu, K. K., Dennis, B. H., Shimakawa, T., Conlan, M. G., Davis, C. E. & Williams, O. D. (1993). Associations of fish intake and dietary n-3 polyunsaturated fatty acids with a hypocoagulable profile. The Atherosclerosis Risk in Communities (ARIC) Study. Arteriosclerosis and Thrombosis 13. 1205–1212.CrossRefGoogle ScholarPubMed
Shattil, S. J. (1992). Why is platelet activation useful for assessing thrombotic risk? What are the advantages and limitations of using flow cytometry to measure platelet activation? American Journal of Clinical Nutrition 56, 789S–790S.CrossRefGoogle ScholarPubMed
Simpson, H. C. R., Mann, J. I., Chakrabarti, R., Imeson, J. D., Stirling, Y., Tozer, M., Woolf, L. & Meade, T. W. (1982). Effect of high fibre diet on haemostatic variables in diabetes. British Medical Journal 284, 1608.CrossRefGoogle ScholarPubMed
Slabber, M., Barnard, H. C., Kuyl, J. M. & Badenhorst, C. J. (1992). Effect of a short-term very low calorie diet on plasma lipids, fibrinogen, and factor VII in obese subjects. Clinical Biochemistry 25, 334–335.CrossRefGoogle ScholarPubMed
Spertini, O., Hauert, J. & Bachmann, F. (1992). Reaction of acetaldehyde with human platelets. Thrombosis and Haemostasis 67, 126–130.Google ScholarPubMed
Stamler, J. S. & Slivka, A. (1996). Biological chemistry of thiols in the vasculature and in vascular-related disease. Nutrition Reviews 54, 1–30.CrossRefGoogle ScholarPubMed
Struck, M., Watkins, T., Tomeo, A., Halley, J. & Bierenbaum, M. (1994). Effect of red and white wine on serum lipids, platelet aggregation, oxidation products and antioxidants: a preliminary report. Nutrition Research 14, 1811–1819.CrossRefGoogle Scholar
Stubbs, C. D. & Rubin, R. (1992). Effect of ethanol on platelet phospholipase A2. Lipids 27, 255–260.CrossRefGoogle ScholarPubMed
Sundell, I. B., Dahlen, G. H. & Ranby, M. (1991). Diet-induced changes in glucose and triglycerides are associated with changes in plasminogen activator inhibitor levels. Haemostasis 21, 175–180.Google ScholarPubMed
Sundell, I. B., & Ranby, M. (1993). Oat husk fiber decreases plasminogen activator inhibitor type I activity. Huemostasis 23, 45–50.Google Scholar
Suzuki, T., Yamanchi, K., Yamada, Y., Furumichi, T., Furui, H., Tsuzuki, J., Hayashi, H., Sotobata, I. & Saito, H. (1992). Blood coagulability and fibrinolytic activity before and after physical training during the recovery phase of acute myocardial infarction. Clinical Cardiology 15, 358–364.CrossRefGoogle ScholarPubMed
Svendsen, O. L., Hassager, C., Christiansen, C., Nielsen, J. D. & Winlher, K. (1996). Plasminogen activator inhibitor-I, tissue-type plasminogen activator, and fibrinogen: effect of dieting with or without exercise in overweight postmenopausal women. Arteriosclerosis, Thrombosis. and Vascular Biology 16, 381–385.CrossRefGoogle ScholarPubMed
Takada, A., Takada, Y. & Urano, T. (1994). The physiological aspects of fibrinolysis. Thrombosis Research 76, 1–31.CrossRefGoogle ScholarPubMed
Tanaka, K. & Sueishi, K. (1993). Biology of disease. The coagulation and fibrinolysis systems and atherosclerosis. Laboratory Investigation 69, 5–17.Google Scholar
Tholstrup, T., Andreasen, K. & Sanstrom, B. (1996). Acute effect of high-fat meals rich in either stearic or myristic acid on hemostatic factors in healthy young men. American Journal of Clinical Nutrition 64, 168–176.CrossRefGoogle ScholarPubMed
Thomsen, C., Rasmussen, O. W., Ingerslev, J. & Hermansen, K. (1995). Plasma levels of von Willebrand factor in non-insulin-dependent diabetes mellitus are influenced by dietary monounsaturated fatty acids. Thrombosis Research 77, 347–356.CrossRefGoogle ScholarPubMed
Tripodi, A., Mannucci, P. M., Chantarangkul, V., Bottasso, B., Arbini, A. A., DellaBella, S. & Scorza, R. (1993). Markers of procoagulant imbalance in patients with localized melanomas and autoimmune disorders. British Journal of Haematologv 84, 670–674.CrossRefGoogle ScholarPubMed
Ulbricht, T. L. V. & Southgate, D. A. T. (1991). Coronary heart disease: seven dietary factors. Lancet 338, 985–992.CrossRefGoogle ScholarPubMed
Uno, M., Tsuji, H., Watanabe, M., Takada, O., Kobayashi, K., Takabuchi, H. et al. (1989). Application of thrombin-antithrombin III complex for detecting a latent hypercoagulable state in patients with coronary artery disease. Japanese Circulation Journal 53, 1185–1191.CrossRefGoogle ScholarPubMed
Vague, P., Juhan-Vague, I., Aillaud, M. F., Badier, C., Viard, R., Alessi, M. C. & Collen, D. (1986). Correlation between blood fibrinolytic activity, plasminogen activator inhibitor level, plasma insulin level, and relative body weight in normal and obese subjects. Metabolism 35, 250–253.CrossRefGoogle ScholarPubMed
Vaisanen, S., Rankinen, T., Penttila, I. & Rauramaa, R. (1995). Factor VII coagulant activity in relation to serum lipoproteins and dietary fat in middle-aged men. Thrombosis and Haemostasis 73, 435–438.Google ScholarPubMed
Van Bennekum, A. M., Emeis, J. J., Kooistra, T. & Hendriks, H. F. J. (1993). Modulation of tissue-type plasminogen activator by retinoids in rat plasma and tissues. American Journal of Physiology 264, R931–R937.Google ScholarPubMed
Van der Bom, J. G., Bots, M. L.Haverkate, F.. Grobbee, D. E. & Kluft, C. (1996). Fibrinolytic capacity and risk of myocardial infarction. Fibrinolysis 10 (Suppl. 2), 9–12.CrossRefGoogle Scholar
Van Giezen, J. J. J., Boon, G. d. i. A., Jansen, J. W. C. M. & Bouma, B. N. (1993). Retinoic acid enhances fibrinolytic activity in-vivo by enhancing tissue type plasminogen activator (t-PA) activity and inhibits venous thrombosis. Thrombosis and Haemostasis 69, 381–386.Google ScholarPubMed
Vanninen, E., Laitinen, J. & Uusitupa, M. (1994). Physical activity and fibrinogen concentration in newly diagnosed NIDDM. Diabetes Care 17, 1031–1038.CrossRefGoogle ScholarPubMed
Veenstra, J., Kluft, C., Van der Pol, H., Dooijewaard, G. & Schaafsma, G. (1993). Acute effects of moderate alcohol consumption on fibrinolytic factors in healthy middle-aged men. Fibrinolysis 7, 177–183.CrossRefGoogle Scholar
Veldman, F. J. (1996). Possible mechanisms through which pectin influences fibrinogen concentration and fibrin network structure. PH. D.thesis, PU for CHE, Potchefstroom, 238 pp.Google Scholar
Velthuis-te Wierik, E. J. M., Kluft, C., Van den Berg, H. & Weststrate, J. A. (1996). Consumption of reduced-fat products, haemostatic parameters and oral glucose tolerance test. Fibrinolysis 10, 159–166.CrossRefGoogle Scholar
Venter, C. S. & Vorster, H. H. (1989). Possible metabolic consequences of fermentation in the colon for humans. Medical Hypotheses 29, 161–166.CrossRefGoogle ScholarPubMed
Venter, C. S., Vorster, H. H., Silvis, N., Kruger, A., Mia, F. & Seftel, H. C. (1992). Determinants of plasma fibrinogen level in South African communities. In Fibrinogen: a ‘new’ cardiovascular risk facror, pp. 166–171 [Ernst, E, Koenig, W, Lowe, G. D. O and Meade, T. W. editors]. Oxford: Blackwell.Google Scholar
Venter, C. S., Vorster, H. H. & Van der Nest, D. G. (1990). Comparison between physiological effects of konjac-glucomannan and propionate in baboons fed ‘western’ diets. Journal of Nutrition 120, 1046–1053.CrossRefGoogle ScholarPubMed
Venter, C. S., Vorster, H. H., Van der Nest, D. G. & Wight, A. W. (1991). Effects of Konjac-glucomannan and proprionate on plasma fibrinogen and serum and liver lipids in Zucker rats. South African Journal of Clinical Nutrition 4(1), 6–11.Google Scholar
Ventraete, M. (1991). Biology and chemistry of thrombosis. In Thrombolysis: basic contriburions and clinical progress, pp. 3–16 [Haber, E and Braunwald, E editors]. St Louis, MO: Mosby Year Book Inc.Google Scholar
Visudhiphan, S., Poolsuppasit, S., Piboonnukarintr, O., & Tumliang, S. (1982). The relationship between high fibrinolytic activity and daily capsicum ingestion in Thais. American Journal of Clinical Nutrition 35, 1452–1458.CrossRefGoogle ScholarPubMed
Vorster, H. H., Badenhorst, C., Bamard, H. C., Walker, A. R. P., Kruger-Locke, M. M. & Van Jaarsveld, P. (1989). Effects of weight reduction on plasma fibrinogen levels and other metabolic variables in obese women. South African Journal of Clinical Nutrition 12(2), 8–13.Google Scholar
Vorster, H. H., Benadé, A. J. S., Barnard, H. C., Locke, M. M., Silvis, N.Venter, C. S., Smuts, C. M., Engelbrecht, G. P. & Marais, M. P. (1992). Egg intake does not change plasma lipoprotein and coagulation profiles. American Journal of Clinical Nutrition 55, 400–410.CrossRefGoogle Scholar
Vorster, H. H., Cummings, J. H. & Veldman, F. J. (1997). Diet and haemostasis: time for nutrition science to get more involved. British Journal of Nutrition 77, 671–684.CrossRefGoogle ScholarPubMed
Vorster, H., Jerling, J., Oosthuizen, W., Cummings, J., Bingham, S., Magee, L., Mulligan, A. & Runswick, S. (1996). Tea drinking and haemostasis: a randomized, placebo-controlled crossover study in free-living subjects. Haemostasis 26, 58–64.Google ScholarPubMed
Vorster, H. H., Silvis, N., Venter, C. S., Van Ryssen, J. J., Huisman, H., Van Eeden, T. S. & Walker, A. R. P. (1987). Serum cholesterol, lipoproteins and plasma coagulation factors in South African blacks on a high egg but low-fat intake. American Journal of Clinical Nutrition 46, 52–57.CrossRefGoogle ScholarPubMed
Vorster, H. H. & Venter, C. S. (1994). Fibrinogen—a cardiovascular risk factor. Cardiovascular Journal of Southern Africa 5, 117–123.Google Scholar
Walker, F. J. & Fay, P. J. (1992). Regulation of blood coagulation by the protein C system. FASEB Journal 6, 2561–2567.CrossRefGoogle ScholarPubMed
Wang, J. S., Jen, C. J. & Chen, H. I. (1995). Effects of exercise training and deconditioning on platelet function in men. Arteriosclerosis. Thrombosis, and Vascular Biology 15, 1668–1674.CrossRefGoogle ScholarPubMed
Weidtmann, A., Scheithe, R., Hrboticky, N., Pietsch, A., Lorenz, R. & Siess, W. (1995). Mildly oxidized LDL induces platelet aggregation through activation of phospholipase A2. Arteriosclerosis, Thrombosis and Vascular Biology 15, 1131–1138.CrossRefGoogle ScholarPubMed