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Synthesis of Functionalized Targeted Polyamides

Published online by Cambridge University Press:  15 February 2011

P. M. Mungara  and
K. E. Gonsalves
P. M. Mungara
Affiliation:
Polymer Science Program, Institute of Materials Science, U-136 & Department of Chemistry, University of Connecticut, Storrs, CT 06269
K. E. Gonsalves
Affiliation:
Polymer Science Program, Institute of Materials Science, U-136 & Department of Chemistry, University of Connecticut, Storrs, CT 06269
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Abstract

A synthetic approach to polyamides containing the tyrosine-leucine linkage is presented. The diphenyl phosphoryl azide, (DPPA), coupling technique was utilized to synthesize the monomers. Solution polymerization of monomer I, tyrosylleucyliminohexamethyleneiminoleucyltyrosine, with adipoyl and sebacoyl chlorides gave polymers with intrinsic viscosities of 0.18 dL/g and 0.13 dL/g respectively in 90% formic acid. Interfacial polymerization of the monomer yielded a fibrous crosslinked material which was found to be a poly(amide-ester) by IR spectroscopic analysis.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 330: Symposium S – Biomolecular Materials by Design , 1993 , 13
Copyright
Copyright © Materials Research Society 1994

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References

REFERENCES

1. Kumar, G.S., Biodegradable Polymers, Prospect and Progress, (Marcel Dekker Inc., New York, 1987).Google Scholar
2. Anderson, J. M., Gibbons, D. F., Martin, R. L., Hiltner, A. and Woods, R. J., Biomed. Mater. Res. Symp. 5 (1), 197 (1974).CrossRefGoogle Scholar
3. Hayashi, T., and Iwatsuki, M., Biopolymers 29,549 (1990).CrossRefGoogle Scholar
4. Gonsalves, K. E. and Mungara, P. M., Polym. Commun. in press.Google Scholar
5. Gonsalves, K. E. and Mungara, P. M., Chem. Mater. 5, 1242 (1993).Google Scholar
6. Shioiri, T., Ninomiya, K. and Yamada, S., J. Amer. Chem. Soc. 94, 6203 (1972).Google Scholar
7. Yamada, S., Ikota, N. and Shioiri, T., J. Amer. Chem. Soc. 97, 7175 (1975).CrossRefGoogle Scholar
8. Morgan, P. W., Kwolek, S. L., J. Polymer Sci. A 2, 185 (1964).Google Scholar
9. Gonsalves, K. E., Chen, X. and Wong, T. K., J. Mater. Chem. 1(4), 643 (1991).CrossRefGoogle Scholar
10. Gonsalves, K. E., Chen, X. and Cameron, J. A., Macromolecules 25, 3309 (1992).CrossRefGoogle Scholar
11. Nishi, N., Tsunemi, M., Hayasaka, H., Nakajima, B. and Tokura, S., Makromol. Chem. 192, 1789 (1991).CrossRefGoogle Scholar