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Surface Modification of Polymeric Materials and its Effect on Blood Compatibility

Published online by Cambridge University Press:  26 February 2011

Debra A. Wrobleski ,
David L. Cash ,
Thomas Archuleta ,
Barry L. Barthell ,
Ram Kossowsky ,
Jerry E. London ,
Bruce E. Lehnert  and
David V. Duchane
Debra A. Wrobleski
Affiliation:
Material and Technology Division
David L. Cash
Affiliation:
Material and Technology Division
Thomas Archuleta
Affiliation:
Material and Technology Division
Barry L. Barthell
Affiliation:
Material and Technology Division
Ram Kossowsky
Affiliation:
Penn State University, State College, PA 16801
Jerry E. London
Affiliation:
Life Sciences Division, Los Alamos National Laboratory, Los Alamos, NM 87545
Bruce E. Lehnert
Affiliation:
Life Sciences Division, Los Alamos National Laboratory, Los Alamos, NM 87545
David V. Duchane
Affiliation:
Material and Technology Division
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Abstract

The surfaces of commercially available polymeric materials have been modified through two techniques, the chemical infusion process and physical vapor deposition. The surfaces of poly(methylmethacrylate) (PMMA) have been modified through a chemical infusion process by treatment of the sample with a solution containing varying amounts of titanium(IV)isopropoxide and polyvinylpyrrolidone (PVP). The surfaces of silicone rubber samples have been coated with a thin coating of titanium dioxide with an ion beam sputtering technique. The treated samples were characterized by scanning electron microscopy, optical microscopy, and neutron activation analysis. The infused samples were evaluated for blood compatibility using two biological assays: 1) an adherence assay in which the adherence of human polymorphonuclear leukocytes to the samples was determined, and 2) a hemolysis assay using rat blood erythrocytes to determine the hemolytic activity of the samples. Based on the results of these assays, the PMMA samples treated with PVP alone resulted in an improvement in reactivity with the blood cells.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 110: Symposium M – Biomedical Materials and Devices , 1987 , 655
Copyright
Copyright © Materials Research Society 1988

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