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Surface Interactions for Controlling the Microfluidic Separation of Polymeric Microspheres

Published online by Cambridge University Press:  25 October 2011

Alireza Sadeghi ,
Jonathan Howse ,
Steve Ebbens  and
Bruno De Geest
Alireza Sadeghi
Affiliation:
Chemical and Process Engineering Department, University of Sheffield, Sheffield S1 3JD
Jonathan Howse
Affiliation:
Chemical and Process Engineering Department, University of Sheffield, Sheffield S1 3JD
Steve Ebbens
Affiliation:
Chemical and Process Engineering Department, University of Sheffield, Sheffield S1 3JD
Bruno De Geest
Affiliation:
Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Ghent University, B-9000 Ghent
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Abstract

Applications of self-assembled monolayers (SAMs) formed by the adsorption of alkanethiols onto gold surfaces have had a widespread growth in adhesion investigations, interfacial interaction investigations and other interfacial phenomena in recent years. As computational modelling showed that modified surfaces can segregate compliant microspheres, a microfluidic flow cell was designed to roll polymeric microcapsules on surfaces with different chemistries, in order to obtain experimental data to validate previous results. Particle image velocimetry showed that rolling speed of microcapsules is affected by surface chemistry. The velocity of vesicles rolling on thiol surfaces with positive of negative charged head groups was significantly lower than vesicles rolling on thiol surfaces with a hydrocarbon chain head group and pure gold surface respectively. Since fabrication of patterned SAMs with different thiol surfaces is possible through oxidation by UV light, our results point to a facile method for carrying out a continuous separation process.

Keywords

biomimetic (assembly)fluidicsadhesion
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1357: Symposium LL – Biomimetic Engineering of Micro- and Nanoparticles , 2011 , mrss11-1357-ll06-08
Copyright
Copyright © Materials Research Society 2011

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References

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