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Structural investigation of Neptunium(IV) in toxicological processes

Published online by Cambridge University Press:  26 February 2011

Christophe Den Auwer ,
Philippe Moisy ,
Dominique Guillaumont ,
Claude Vidaud ,
Harald Funke  and
Christoph Hennig
Christophe Den Auwer
Affiliation:
christophe.denauwer@cea.fr, CEA Marcoule, DEN/DRCP/SCPS, -, Bagnols sur Ceze, -, 30207, France, + 4 66 79 63 25
Philippe Moisy
Affiliation:
philippe.moisy@cea.fr, CEA Marcoule, DEN/DRCP/SCPS, France
Dominique Guillaumont
Affiliation:
dominique.guillaumont@cea.fr, CEA Marcoule, DEN/DRCP/SCPS, France
Claude Vidaud
Affiliation:
claude.vidaud@cea.fr, CEA Marcoule, DSV/DIEP/SBTN
Harald Funke
Affiliation:
funke@esrf.fr, FZR, ROBL at ESRF, Germany
Christoph Hennig
Affiliation:
hennig@esrf.fr, FZR, ROBL at ESRF, Germany
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Abstract

General understanding of intramolecular interactions engaged in molecular actinide species, in other words physical chemical mechanisms that drive the affinity of chelating ligands for actinide cations still needs to be deepened. In this field, X ray Absorption Spectroscopy has been extensively used as a structural and electronic metal cation probe. Combination with more traditional spectroscopic techniques as spectrophotometry is an ideal tool for the understanding of the chelation mechanism. Metallobiomolecules are considered as elaborate inorganic complexes with well-designed metal active sites. Although the various interaction processes between essential cations to biology and proteins are widely studied, focus on the actinide family is more seldom. Actinide impact to biological cycles has been motivated by risk assessments related to the wide use of nuclear fuel sources and industrial or military applications. In particular, the interactions of these cations with the biologically active complexation sites are only partially understood.

Keywords

actinideextended x-ray absorption fine structure(EXAFS)biological
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 893: Symposium JJ – Actinides 2005 – Basic Science, Applications and Technology , 2005 , 0893-JJ09-01
Copyright
Copyright © Materials Research Society 2006

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