Hostname: page-component-7479d7b7d-68ccn Total loading time: 0 Render date: 2024-07-08T20:08:13.866Z Has data issue: false hasContentIssue false
  • English
  • Français

Resorbable Synthetic Bone Grafts Formed From a Silicon Stabilized Calcium Phosphate Bioceramic

Published online by Cambridge University Press:  15 February 2011

S. Langstaff ,
M. Sayer ,
T. Smith  and
S. Pugh
S. Langstaff
Affiliation:
Department of Physics, Queen's University, Kingston, ON K7L 3N6
M. Sayer
Affiliation:
Department of Physics, Queen's University, Kingston, ON K7L 3N6
T. Smith
Affiliation:
Millenium Biologix, 785 Midpark Dr, Suite200, Kingston, ON K7M 7G3
S. Pugh
Affiliation:
Millenium Biologix, 785 Midpark Dr, Suite200, Kingston, ON K7M 7G3
Get access

Abstract

Synthetic bone grafts resistant to random dissolution at physiological pH, yet capable of being gradually resorbed in vitro by osteoclasts have been created. Bulk ceramics and ceramic coatings formed from an additive stabilized colloidal sol possess two characteristic features: a phase mixture of calcium hydroxyapatite (HA) and a silicon stabilized tricalcium phosphate, and a microporous morphology based on inter-connected particles (0.2-1.0 μm). The characteristic phase composition arises during sintering through substitution reactions where silicon enters the calcium phosphate lattice under conditions of high chemical reactivity. Evidence for in vitro resorption lacunae on bulk ceramics is presented.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 550: Symposium GG/HH/II – Biomedical Materials-Drug Delivery, Implants and Tissue Engr , 1998 , 313
Copyright
Copyright © Materials Research Society 1999

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Ito, K., and Ooi, Y.. CRC Handbook of Bioactive Ceramics, edited by Yamamuro, T., Hench, L. and Wilson, J. (CRC Press, Boca Raton, Florida, 1990), pp. 39–51.Google Scholar
2. Ohgushi, H., et al. J. Biomed. Mater. Res. 24, 1563 (1990).Google Scholar
3. Millenium Biologix Inc. Patent. WP 94/26872. (1994).Google Scholar
4. Davies, J., Shapiro, G., andLowenberg, B.. Cells and Materials 3(3), 245 (1993).Google Scholar
5. Qiu, Q., et al. Cells and Materials 3(4), 351 (1993).Google Scholar
6. Langstaff, S., et al. Mat. Res. Soc. Symp. Proc. 414, 87 (1996).Google Scholar
7. Qiu, Q.. M.Sc. Thesis, Queen's University (1992).Google Scholar
8. Langstaff, S.. PhD Thesis, Queen's University (1998).Google Scholar
9. Langstaff, S., et al. Resorbable Bioceramics based on Stabilized Calcium Phosphates: Part I Rational Design, Sample Preparation and Materials Characterization (to be published in Biomaterials 1999)Google Scholar
10. Hench, L., et al. J Biomed. Mater. Res. Symp. 2, 117 (1972).Google Scholar
11. Hench, L.. J. Am. Ceram. Soc. 74(7), 1487 (1991).Google Scholar
12. Ducheyne, P.. J Biomed. Mater. Res. 19, 273 (1985).Google Scholar
13. Pugh, S., Smith, T., Sayer, M., andLangstaff, S.. International PCT Application No: PCT/CA98/00046 (1998).Google Scholar
14. JCPDS-International Centre for Diffraction Data, American Society for Testing and Materials, Powder Diffraction File (Inorganic and Organic). (Swarthmore, Pa.JCPDS-International Centre for Diffraction Data, 1991)Google Scholar
15. Anonymous, X-Ray Absorption: Principles, Applications, Techniques of EXAFS, SEXAFS and XANES 1 ed. (John Wiley & Sons, Toronto, 1988).Google Scholar
16. Sham, T.K. to Langstaff, S. (1998) personal communication.Google Scholar
17. Shurvell, H. to Hesp, S. (1997) personal communication.Google Scholar