Hostname: page-component-848d4c4894-cjp7w Total loading time: 0 Render date: 2024-06-21T17:48:37.831Z Has data issue: false hasContentIssue false
  • English
  • Français

Quantitative Investigations of Nanoscale Elasticity of Nanofibrillar Matrices

Published online by Cambridge University Press:  31 January 2011

Volkan M Tiryaki ,
Adeel Ahmed Khan ,
Alicia Pastor ,
Raed A Alduhaileb ,
Roberto Delgado-Rivera ,
Ijaz Ahmed ,
Sally A Meiners  and
Virginia M Ayres
Volkan M Tiryaki
Affiliation:
tiryakiv@msu.edu, Michigan State University, College of Engineering, East Lansing, Michigan, United States
Adeel Ahmed Khan
Affiliation:
adeel_net@yahoo.com, Western Michigan University, College of Engineering and Applied Sciences, Kalamazoo, Michigan, United States
Alicia Pastor
Affiliation:
pastorle@msu.edu, Michigan State University, Center for Advanced Microscopy, East Lansing, Michigan, United States
Raed A Alduhaileb
Affiliation:
alduhail@msu.edu, Michigan State University, College of Engineering, East Lansing, Michigan, United States
Roberto Delgado-Rivera
Affiliation:
robertde@eden.rutgers.edu, Rutgers University, The State University of New Jersey, Piscataway, New Jersey, United States
Ijaz Ahmed
Affiliation:
ahmedij@umdnj.edu, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, United States
Sally A Meiners
Affiliation:
meiners@umdnj.edu, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, United States
Virginia M Ayres
Affiliation:
ayresv@msu.edu, Michigan State University, College of Engineering, East Lansing, Michigan, United States
Get access

Abstract

Recent research indicates that nanophysical properties as well as biochemical cues can influence cellular re-colonization of a tissue scaffold. It has also been shown nanoscale elasticity can strongly influence cellular responses. In the present work, quantitative investigations of the elasticity of a nanofibrillar matrix scaffold that has demonstrated promise for spinal cord injury repair are compared with complementary transmission electron microscopy investigations, performed to assess nanofiber internal structures. Interpretive model improvements are identified and discussed.

Keywords

elastic propertiestissuetransmission electron microscopy (TEM)
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1240: Symposium WW – Polymer Nanofibers–Fundamental Studies and Emerging Applications , 2009 , 1240-WW09-13
Copyright
Copyright © Materials Research Society 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Vasita, R. and Katti, D.S. Int. J. Nanomedicin Nanomedicine 1, 15, (2006).Google Scholar
2 Discher, D.E. Janmey, P. and Wang, Y.L. Science, 310, 1139 (2005).Google Scholar
3 Engler, A.J. Sen, S. Sweeney, H.L. and Discher, D.E. Cell 126, 677 (2006).Google Scholar
4 Even-Ram, S. and Yamada, K.M. Current Opinion in Cell Biology 17, 524 (2005).Google Scholar
5 Delgado-Rivera, R., Harris, S.L. Ahmed, I. Babu, A.N. Patel, R. Kamal, J. Ayres, V.M. Flowers, D. and Meiners, S. Matrix Biology 28, 137, (2009).Google Scholar
6 Lin, D.C. Dimitriadis, E.K. and Horkay, F. Transaction of the ASME 129, 904 (2007).Google Scholar
7 Fan, Y. Chen, Q. Ayres, V.M. Baczewski, A.D. Udpa, L. and Kumar, S. Int. J. Nanomedicine 2, 651 (2007).Google Scholar
8 Fan, Y. Chen, Q. Kumar, S. Baczewski, A.D. Udpa, L. Ayres, V.M. and Rice, A.F. Surface and Interfacial Nanomechanics Nanomechanics, edited by Cook, R.F. Ducker, W. Szlufarska, I. and Antrim, R.F., (Mater. Res. Soc. Symp. Proc. 1021E 1021E, Warrendale, PA,2007) 1021–HH05.Google Scholar
9 Ayres, V.M. Chen, Q. Fan, Y. D.A Flowers, A. Meiners, S. Ahmed, I. and Delgado-Rivera, R., Int. J. Nanomanufact Nanomanufacturing, 6, (2010) (in press).Google Scholar
10 Meiners, S., Ahmed, I., Ponery, A.S. Amor, N. Harris, S.L. Ayres, V.M. Fan, Y. and Babu, A.N. Polymer Int. 56, 1340 (2007).Google Scholar
11 Meiners, S. Harris, S.L. Delgado-Rivera, R., Ahmed, I. Babu, A.N. Patel, R.P. Crockett, D.P. in Nanofibers: Fabrication, Performance, and Applications Applications, edited by Chang, W.N.. (Nova Science Publishers, Inc., Hauppage, NY, 2009), pp. 327–343.Google Scholar