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Osteoblast Adhesion on Biodegradable Polymer Substrates

Published online by Cambridge University Press:  15 February 2011

Susan L. Ishaug ,
Michael J. Yaszemski ,
Rena Bizios  and
Antonios G. Mikos
Susan L. Ishaug
Affiliation:
Institute of Biosciences and Bioengineering, Rice University, Houston, TX
Michael J. Yaszemski
Affiliation:
Departement of Orthopaedic Surgery, Wilford Hall Medical Center, Lackland AFB, TX
Rena Bizios
Affiliation:
Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY
Antonios G. Mikos
Affiliation:
Institute of Biosciences and Bioengineering, Rice University, Houston, TX
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Abstract

We have investigated the adhesion of rat osteoblasts on biodegradable poly(α-hydroxy ester) films as an in vitro model of bone regeneration. Osteoblasts cultured on poly(L-lactic acid), poly(DL-lactic-co-glycolic acid) copolymers, and poly(glycolic acid) films for 14 days grew with rates comparable to those observed for tissue culture polystyrene and retained their phenotype as expressed by activity of alkaline phosphatase and collagen synthesis.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 331: Symposium T – Biomaterials for Drug and Cell Delivery , 1993 , 121
Copyright
Copyright © Materials Research Society 1994

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