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Nanobiomaterials For Controlled Release Of Drugs & Vaccine Delivery

Published online by Cambridge University Press:  01 February 2011

Ashok Vaseashta ,
A. Erdem  and
I. Stamatin
Ashok Vaseashta
Affiliation:
prof.vaseashta@marshall.edu, Marshall University, Physics and Physical Sciences, One John Marshall Drive, Huntington, WV, 25755-2570, United States, 304 696 2755, 304 696 2755
A. Erdem
Affiliation:
arzum.erdem@ege.edu.tr, Ege University, Analytical Chemistry Department, 35100 Bornova, Izmir, N/A, N/A, Turkey
I. Stamatin
Affiliation:
istarom@polymer.fizica.unibuc.ro, University of Bucharest, 3 Nano & Alternative Energy Sources Research Center, Faculty of Physics, Bucharest- Magurele, Bucharest, N/A, Romania
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Abstract

A number of natural and synthetic, and biodegradable polymers were investigated and remain to be elucidated for both soft and hard tissue repair, and for possible construction of excipient therapeutic templates. Nonwoven matrices from poly (ε-caprolactone) (PCL) homopolymers and poly (L-lactide/ε-caprolactone) (PLLA/CL) copolymers by electrospinning process were investigated for possible applications in burn/wound dressings. Efforts are currently underway to control the release characteristics of these biodegradable fibers by varying aliphatic polyesters. This perspective will have a profound effect on the time-controlled transport of vaccine to a targeted site. These materials will play a key role in developing novel chemotherapeutic agents that could be important in targeting specific genes and may provide selective control of gene expression. Furthermore, these fibers-by-design address many issues relating to the fundamental challenges in the synthesis of novel, biocompatible and safe delivery of vaccine and nanofiber materials to foster antibacterial and/or hygienic functionality, System-on-Fibers (SoF), and will have tremendous application in global security and defense.

Keywords

biomedicalnanoscalenanostructure
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 920: Symposium S – Smart Nanotextiles , 2006 , 0920-S06-06
Copyright
Copyright © Materials Research Society 2006

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