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Nano Monitors for Identification of Vulnerable Cardio-vascular Plaque

Published online by Cambridge University Press:  01 February 2011

Shalini Prasad ,
Thomas Barrett  and
John Carruthers
Shalini Prasad
Affiliation:
sprasad@pdx.edu, Portland State University, ECE, 160-11, FAB 1900 SW 4th ave, Portland, OR, 97201, United States, 503-725-3223
Thomas Barrett
Affiliation:
barretth@ohsu.edu, Oregon Health Sciences University, Portland, OR, 97209, United States
John Carruthers
Affiliation:
carruthe@pdx.edu, Portland State University, Physics, Portland, 97201, United States
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Abstract

We describe highly sensitive, non–invasive, label-free, electrical detection of protein biomarkers using nanoporous alumina membrane based electrochemical conductance based devices. The principle of operation of these sensors are based on electrochemical conductance varitions associated with the binding of antibody-antigen complexes to a metallic substrate.In these devices distinct pore clusters are selectively surface functionalized with specific antibodies, that are in turn are incorporated into micro scale arrays. Protein markers were routinely detected at nanomolar concentrations. This opens the potential for developing highly sensitive and selective biomarker detection assays in clinically relevant samples for diagnosis of complex disease state like vulnerable coronary plaque rupture that results in poor post surgical outcomes and other complex diseases.

Keywords

sensorsensorbiomedical
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 926: Symposium CC – Electrobiological Interfaces on Soft Substrates , 2006 , 0926-CC03-02
Copyright
Copyright © Materials Research Society 2006

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