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Micro X-Ray Fluorescence As A High Throughput Screening Method For Combinatorial Chemistry

Published online by Cambridge University Press:  01 February 2011

George J. Havrilla ,
Thomasin Miller ,
Benjamin Warner  and
Cyndi Wells
George J. Havrilla
Affiliation:
Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Thomasin Miller
Affiliation:
Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Benjamin Warner
Affiliation:
Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Cyndi Wells
Affiliation:
Los Alamos National Laboratory, Los Alamos, NM 87545, USA
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Abstract

Micro X-ray fluorescence is used as a high-throughput screening method for combinatorial applications. These include chemical weapon degradation products, catalytic phosphate hydrolysis and radiologic dispersion device metals. In each application the intrinsic elemental signature was utilized to identify the lead hits for the combinatorial screening in locating peptide sequences exhibiting the desired binding characteristics. In addition to being nondestructive, rapid and non-perturbing to the binding event, this method can be used to quantify the amount of target material.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 804: Symposium JJ – Combinatorial and Artificial Intelligence Methods in Materials Science II , 2003 , JJ10.3
Copyright
Copyright © Materials Research Society 2004

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References

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