Hostname: page-component-7c8c6479df-8mjnm Total loading time: 0 Render date: 2024-03-28T10:40:17.617Z Has data issue: false hasContentIssue false

Ionic Polyurethanes: Surface and Blood-Contacting Properties

Published online by Cambridge University Press:  26 February 2011

Ann Z. Okkema
Affiliation:
University of Wisconsin, Department of Chemical Eng., 1415 Johnson Dr., Madison, WI 53706
Thomas A. Giroux
Affiliation:
University of Wisconsin, Department of Chemical Eng., 1415 Johnson Dr., Madison, WI 53706
Timothy G. Grasel
Affiliation:
University of Wisconsin, Department of Chemical Eng., 1415 Johnson Dr., Madison, WI 53706
Stuart L. Cooper
Affiliation:
University of Wisconsin, Department of Chemical Eng., 1415 Johnson Dr., Madison, WI 53706
Get access

Abstract

Sulfonated polyetherurethanes, synthesized by the substitution of 0, 5, 10, 15, and 20% of the urethane nitrogens with propane sultone, were evaluated in this study. The water absorption properties are dramatically affected by the sulfonate content. The surface properties are also found to be influenced by the percentage of sulfonate incorporation. The blood-contacting properties, as determined by both an acute and chronic canine ex vivo experiment, show increased thromboresistance with increased propyl sulfonate incorporation. A unique characteristic of the highly sulfonated polymers is the negligible platelet activation and spreading observed using scanning electron microscopy.

Type
Research Article
Copyright
Copyright © Materials Research Society 1988

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Rembaum, A., Yen, S.P.S., Ingram, M., Newton, J.F., Hu, C.L., Frasher, W.G. and Barbour, B.H., Biomed., Med. Dev., Art. Org. 1, 99199 (1973).Google Scholar
2. Lelah, M.D., Pierce, J.A., Lambrecht, L.K. and Cooper, S.L., J. Colloid Interface Sci. 104, 422439 (1985).Google Scholar
3. Cifonelli, J.A., Adv. Exp. Med. Biol. 52, 95 (1975).Google Scholar
4. Larsson, R., Eriksson, J.C. and Olsson, P., Thrombosis Research 14, 941952 (1979).CrossRefGoogle Scholar
5. Lelah, M.D., Grasel, T.G., Pierce, J.A. and Cooper, S.L., J. Biomed. Mater. Res. 20, 433468 (1986).Google Scholar
6. Saunders, J.H. and Frish, K.C., Polyurethanes: Chemistry and Technology. Part One. Chemistry, (Interscience, New York, 1962) pp. 42.Google Scholar
7. Hwang, K.K.S., Speckhard, T.A. and Cooper, S.L., J. Macromol. Sci.-Phys. B23, 153174 (1984).Google Scholar
8. Grasel, T.G., Pierce, J.A. and Cooper, S.L., J. Biomed. Mater. Res. 21, 815842 (1987).Google Scholar
9. Lelah, M.D., Grasel, T.G., Pierce, J.A. and Cooper, S.L., J. Biomed. Mater. Res. 19, 10111015 (1985).Google Scholar
10. Grasel, T.G. and Cooper, S.L., submitted to J. Biomed. Mater. Res.Google Scholar
11. Lelah, M.D., Lambrecht, L.K. and Cooper, S.L., J. Biomed. Mater. Res. 18, 475496 (1984).CrossRefGoogle Scholar
12. Ip, W.F., Zingg, W. and Sefton, M.V., J. Biomed. Mater. Res. 19, 161178 (1985).Google Scholar
13. Grasel, T.G., Pitt, W.G., Murthy, K.D., McCoy, T.J. and Cooper, S.L., Biomaterials 8, 329340 (1987).Google Scholar
14. Grasel, T.G. and Cooper, S.L., Biomaterials 7, 315328 (1987).Google Scholar