Hostname: page-component-76fb5796d-x4r87 Total loading time: 0 Render date: 2024-04-26T18:21:06.692Z Has data issue: false hasContentIssue false
  • English
  • Français

Increased Osteoblast and Decreased Smooth Muscle Cell Adhesion on Biologically-inspired Carbon Nanofibers

Published online by Cambridge University Press:  21 March 2011

Rachel L. Price ,
Karen M. Haberstroh  and
Thomas J. Webster
Rachel L. Price
Affiliation:
Department of Biomedical Engineering Purdue University, West Lafayette, IN 47907-1296, U. S. A.
Karen M. Haberstroh
Affiliation:
Department of Biomedical Engineering Purdue University, West Lafayette, IN 47907-1296, U. S. A.
Thomas J. Webster
Affiliation:
Department of Biomedical Engineering Purdue University, West Lafayette, IN 47907-1296, U. S. A.
Get access

Abstract

Osteoblast (the bone-forming cells) and smooth muscle cell adhesion was investigated on carbon nanofiber formulations of various diameters (specifically, from 60 to 200 nm) and surface energies (from 25 to 140 mJ/m2) in the present in vitro study. Results provided the first evidence that osteoblast adhesion increased with decreased carbon nanofiber diameter after 1 hour. In contrast, smooth muscle cell adhesion was not dependent on carbon nanofiber diameter. Moreover, the present study demonstrated that smooth muscle cell adhesion decreased with increased carbon nanofiber surface energy after 1 hour. Alternatively, osteoblast adhesion was not affected by carbon nanofiber surface energy. Since adhesion is a crucial prerequisite for subsequent functions of cells (such as the deposition of bone by osteoblasts), the present results of controlled adhesion of both osteoblasts and a competitive cell line (i.e., smooth muscle cells) demonstrate that carbon nanofibers with small diameters and high surface energies may become the next-generation of orthopedic implant materials to enhance new bone synthesis. These criteria may prove critical in the clinical success of bone prostheses.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 676: Symposium Y – Synthesis, Functional Properties and Applications of Nanostructures , 2001 , Y9.7
Copyright
Copyright © Materials Research Society 2001

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Kaplan, F. S., Hayes, W. C., Keaveny, T. M., Boskey, A., Einhorn, T. A., and Iannotti, J.P., Orthopaedic Basic Science, (Am. Acad. Orth. Surg., Columbus, OH, 1994).Google Scholar
2. Webster, T. J., Siegel, R. W., and Bizios, R., Proceedings of the 11th International Symposium on Ceramics in Medicine, ed. LeGeros, R. Z. and LeGeros, J. P. (World Scientific Publishing Co., 1998) pp. 273.Google Scholar
3. Haberstroh, K. M., Kaefer, M., Retik, A. B., Freeman, M. R., and Bizios, R., J. Urology 162, 2114 (1999).Google Scholar
4. Dee, K. C., Andersen, T. T., and Bizios, R., J. Biomed. Mat. Res., 40, 371 (1998).Google Scholar
5. Webster, T. J., Siegel, R. W., and Bizios, R., Biomater., 20, 1222 (1999).Google Scholar
6. Webster, T. J., Siegel, R. W., and Bizios, R., Nano. Mater., 12, 983 (1999).Google Scholar
7. Webster, T. J., Celaletdin, E., Doremus, R. H., Siegel, R. W., and Bizios, R., J. Biomed. Mat. Res., 51, 475 (2000).Google Scholar
8. Webster, T. J., Ph.D. Thesis, Rensselaer Polytechnic Institute (2000).Google Scholar