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In vitro Evaluation of Arabinoxylan Gels as an Oral Delivery System for Insulin

Published online by Cambridge University Press:  28 November 2012

E. Carvajal-Millan ,
C. Berlanga-Reyes ,
A. Rascón-Chu ,
A. L. Martínez-López ,
J. A. Márquez-Escalante ,
A. C. Campa-Mada  and
K. G. Martínez-Robinson
E. Carvajal-Millan
Affiliation:
CTAOA, Laboratory of Biopolymers
C. Berlanga-Reyes
Affiliation:
CTAOA, Laboratory of Biopolymers
A. Rascón-Chu
Affiliation:
CTAOV. Research Center for Food and Development, CIAD, A.C. Carretera a La Victoria Km. 0.6, Hermosillo, Sonora, 83000 Mexico.
A. L. Martínez-López
Affiliation:
CTAOV. Research Center for Food and Development, CIAD, A.C. Carretera a La Victoria Km. 0.6, Hermosillo, Sonora, 83000 Mexico.
J. A. Márquez-Escalante
Affiliation:
CTAOA, Laboratory of Biopolymers
A. C. Campa-Mada
Affiliation:
CTAOA, Laboratory of Biopolymers
K. G. Martínez-Robinson
Affiliation:
CTAOA, Laboratory of Biopolymers
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Abstract

Arabinoxylan gels are receiving increasing attention as oral delivery systems of biomolecules for therapeutic purposes. The aim of this research was to evaluate arabinoxylan gels as an oral delivery system for insulin, representing a painless therapy for diabetics. Gels at two concentrations of arabinoxylan were prepared (2.5 and 3.5 % w/v). One concentration of insulin (0.05 % w/v) entrapped in the arabinoxylan gels was investigated. At the end of gelation elasticity (G’) values were 11 and 20 for gels at 2.5 and 3.5% (w/v) in arabinoxylan, respectively. The presence of insulin in the gels did not affect the values of G’. The apparent diffusion coefficient for insulin decreased from 1.30 x 10-7 to 1.09 x 10-7 cm2/s when the concentration of arabinoxylan in the gel increased from 2.5 to 3.5% (w/v). The percentage of proteolysis for insulin entrapped in the gels at 2.5 and 3.5% in arabinoxylan (w/v) were 35 and 17%, respectively, in relation to 100% hydrolysis of insulin in solution. Results indicate that arabinoxylan gels could be potential candidates as oral delivery systems for insulin.

Keywords

BiologicalBiomedicalChemical composition
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1487: Symposium S4B – Biomaterials for Medical Applications-2012 , 2012 , imrc12-s4b-p034
Copyright
Copyright © Materials Research Society 2012 

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