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The Feasibility of a Semiconductor-Laser Glucose-Detection System for Insulin-Pump Therapy

Published online by Cambridge University Press:  26 February 2011

I. C. Arrieta ,
D. E. Burk  and
C. Batich
I. C. Arrieta
Affiliation:
Department of Electrical Engineering, University of Florida, Gainesville, Florida 32611
D. E. Burk
Affiliation:
Department of Electrical Engineering, University of Florida, Gainesville, Florida 32611
C. Batich
Affiliation:
Department of Materials Science, University of Florida, Gainesville, Florida 32611
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Abstract

A potentially implantable semiconductor-laser-based sensor is demonstrated to be feasible for glucose detection at concentrations found in the human blood. In the system, the monochromatic, linearly polarized light from a diode laser is directed into an external cavity with a second diode laser at the far end. The cavity is filled with a glucose solution of varying physiological concentrations. The interference of the rotated, polarized light from the first diode laser with that of the second laser is monitored by a photodiode, forming an optoelectronic pair with the first diode laser. A variation in glucose concentration of 0.1 to 0.3 g/dl results in a 5% variation in the photodiode current. This variation is sufficient to provide feedback to an insulin pump.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 110: Symposium M – Biomedical Materials and Devices , 1987 , 429
Copyright
Copyright © Materials Research Society 1988

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References

1. Saudek, C. D., et al., Diabetes, 36, 77A (1987).Google Scholar
2. “Implantable Glucose Sensors - The State of the Art”, Workshop at Schloss Reisensburg, Jan. 1987.Google Scholar
3. Arrieta, I. C., Burk, D. E., and Batich, C. D., Diabetes, 36, 77A (1987).Google Scholar
4. Rabinovitch, B., March, W. F., and Adams, R. L., Diabetes Care, 5, 254–258 (1982).Google Scholar