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Fabrication of Ordered Sub-Micron Topographies on Large-Area Poly(Urethane Urea) by Two-Stage Replication Molding

Published online by Cambridge University Press:  15 March 2011

Keith R. Milner ,
Mallory Balmer ,
Henry J. Donahue ,
Alan J. Snyder  and
Christopher A. Siedlecki
Keith R. Milner
Affiliation:
Dept of Bioengineering, College of Medicine, Pennsylvania State University, Hershey, PA17033 Department of Surgery, College of Medicine, Pennsylvania State University, Hershey, PA17033
Mallory Balmer
Affiliation:
Dept of Bioengineering, College of Medicine, Pennsylvania State University, Hershey, PA17033
Henry J. Donahue
Affiliation:
Musculoskeletal Research Laboratory, Center for Biomedical Devices and Functional Tissue Engineering and Department of Orthopaedics and Rehabilitation, College of Medicine, Pennsylvania State University, Hershey, PA17033
Alan J. Snyder
Affiliation:
Dept of Bioengineering, College of Medicine, Pennsylvania State University, Hershey, PA17033 Department of Surgery, College of Medicine, Pennsylvania State University, Hershey, PA17033
Christopher A. Siedlecki
Affiliation:
Dept of Bioengineering, College of Medicine, Pennsylvania State University, Hershey, PA17033 Department of Surgery, College of Medicine, Pennsylvania State University, Hershey, PA17033
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Abstract

It has been established that material surface topography can have a significant effect on biological cell adhesion, in the absence of changes in surface chemistry. Such investigations were typically performed using surface features with size on the order of microns, comparable to the dimensions of the cells. It has been demonstrated that sub-micron sized topographies that cannot be created via contact lithography also influence cell behavior. The ability to affect cell adhesion is a prime consideration in the development of novel biomaterials. This study reports a two-stage replication molding process for fabricating ordered sub-micron sized features over a large area of biomedical polyether(urethane urea). Such a technique has great applicability in the area of long-term implantable materials as a method for influencing cell-material interactions.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 820: Symposia O/R – Nanoengineered Assemblies and Advanced Micro/Nanosystems , 2004 , R2.8
Copyright
Copyright © Materials Research Society 2004

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