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The Erosion Properties of Polyanhydrides

Published online by Cambridge University Press:  15 February 2011

Lisa Shieh ,
Achim Göpferich  and
Robert Langer
Lisa Shieh
Affiliation:
Rm E25-342, Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139
Achim Göpferich
Affiliation:
Rm E25-342, Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 Current address: Universität Erlangen-Nümberg, Lehrstuhl für Pharmazeutische Technologie, Cauerstrasse 4, 91054 Erlangen, Germany
Robert Langer
Affiliation:
Rm E25-342, Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139
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Abstract

Bioerodible polymers play an important role in parenteral drug delivery. They combine the advantage of controlling drug release and being absorbed by the body after fulfilling their task. The mechanism which controls drug release is the erosion of polymer bulk. In order to understand and control the release it is, therefore, essential to know the erosion mechanism of a biodegradable polymer. We found that the polyanhydrides obey a distinct erosion pattern. An erosion zone (the region where material loss occurs) moves from the surface to the center of the discs. The monomers of which these copolymers are composed also seem to play an important role in degradation and erosion.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 331: Symposium T – Biomaterials for Drug and Cell Delivery , 1993 , 85
Copyright
Copyright © Materials Research Society 1994

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References

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