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Disposable Smart Plastic Biochips For Clinical Diagnostics

Published online by Cambridge University Press:  01 February 2011

Chong H. Ahn ,
Jin-Woo Choi ,
Sanghyo Kim ,
Young-Soo Sohn ,
Aniruddha Puntambekar ,
Suresh Murugesan ,
Gregory Beaucage  and
Joseph H. Nevin
Chong H. Ahn
Affiliation:
Microsystems and BioMEMS Lab University of Cincinnati Department of Electrical and Computer Engineering and Computer Science
Jin-Woo Choi
Affiliation:
Microsystems and BioMEMS Lab University of Cincinnati Department of Electrical and Computer Engineering and Computer Science
Sanghyo Kim
Affiliation:
Microsystems and BioMEMS Lab University of Cincinnati Department of Electrical and Computer Engineering and Computer Science
Young-Soo Sohn
Affiliation:
Microsystems and BioMEMS Lab University of Cincinnati Department of Electrical and Computer Engineering and Computer Science
Aniruddha Puntambekar
Affiliation:
Microsystems and BioMEMS Lab University of Cincinnati Department of Electrical and Computer Engineering and Computer Science
Suresh Murugesan
Affiliation:
Department of Material Science Cincinnati, Ohio 45221-0030
Gregory Beaucage
Affiliation:
Department of Material Science Cincinnati, Ohio 45221-0030
Joseph H. Nevin
Affiliation:
Microsystems and BioMEMS Lab University of Cincinnati Department of Electrical and Computer Engineering and Computer Science
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Abstract

This paper presents an overview of the development of novel disposable smart plastic fluidic biochips for clinical diagnostic applications. The biochip is manufactured using a low-cost, rapid turn around injection molding/embossing process on a plastic substrate. The plastic fluidic biochip uses a novel sPROMs (structurally programmable microfluidic system) approach to achieve passive control of fluidic sequencing [1-2]. The plastic biochip also uses an on-chip pressurized air source for fluidic movement thus eliminating the need for active driving mechanisms and allowing for a truly disposable approach. Furthermore, electrochemical biosensors are also integrated on-chip to analyze various metabolically significant parameters such as PO2(partial pressure of oxygen), Glucose, Lactate,and pH. The fluidic biochip is being developed for point-of-care health monitoring applications where parameters such as small size, simplicity of operation, disposability, reduced cross-contamination are vital. The issues mentioned above are successfully addressed using the approach of this work and are discussed in this paper.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 729: Symposium U – MEMS and BioMEMS , 2002 , U1.8
Copyright
Copyright © Materials Research Society 2002

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References

1. Ahn, C. H., Puntambekar, A., Lee, S., Choi, H., and Hong, C., “Structurally Programmable Microfluidic Systems”, 4th International Symposium on Micro-Total Analysis Systems (μ-TAS), Enschede, The Netherlands, May 14-18, 2000. pp. 205–208.Google Scholar
2. Puntambekar, A., Cho, H., Hong, C., Choi, J., Ahn, C., Kim, S. and Makhijani, V., “A New Fixed-Volume Metering Microdispenser Module Based on sPROMs Technology”, Proc. of Transducers'01, Munich, Germany, pp. 1240–1243, 2001.Google Scholar
3. Kim, S., Trichur, R., Beaucage, G. and Ahn, Chong, “New Plastic Microinjection Molding Technique For Extremely Tall Plastic Microstructure Using Remote Infrared Radiation Heating Method”, Proc. Solid State Sensors, Actuators and Microsystems Workshop, Hilton Head, SC, USA, June 2-6, 2002 (in press).Google Scholar
4. Puntambekar, A., Choi, J., Ahn, C., Kim, S., Bayyuk, S. and Makhijani, V., “An Air-Driven Fluidic Multiplexer Integrated with Microdispensers”, Proc. Micro-Total Analysis Systems (u-TAS), Moneterey Bay, CA, USA, Oct 21-25, 2001, pp. 78–80.Google Scholar
5. Hong, C., Choi, J. and Ahn, Chong, “Disposable Air Bursting Detonators As An Alternative On-Chip Power Source”, Proc. MEMS 2002 IEEE International Conference, Las Vegas, Nevada, USA, Jan 20-24, 2002, pp. 240–243.Google Scholar
6. Gao, C., Choi, J., Dutta, M., Chilukuru, S., Nevin, J., Lee, J., Bisell, M. and Ahn, Chong, “A Fully Integrated Biosensor Array For Measurement Of Metabolic Parameters In Human Blood”, Proc. Second International IEEE-EMBS Special Topic Conference on Microtechnolgies in Medicine and Biology, Madison, WI, USA, May 2-4, 2002 (in press).Google Scholar