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Developing Nanoscale Materials Using Biomimetic Assembly Processes

Published online by Cambridge University Press:  01 February 2011

George D. Bachand ,
Susan B. Rivera ,
Andrew K. Boal ,
Joseph M. Bauer ,
Steven J. Koch ,
Ronald P. Manginell ,
Jun Liu  and
Bruce C. Bunker
George D. Bachand
Affiliation:
Biomolecular Materials and Interfaces, Sandia National Laboratories, Albuquerque, NM, USA
Susan B. Rivera
Affiliation:
Biomolecular Materials and Interfaces, Sandia National Laboratories, Albuquerque, NM, USA
Andrew K. Boal
Affiliation:
Biomolecular Materials and Interfaces, Sandia National Laboratories, Albuquerque, NM, USA
Joseph M. Bauer
Affiliation:
Biomolecular Materials and Interfaces, Sandia National Laboratories, Albuquerque, NM, USA
Steven J. Koch
Affiliation:
Biomolecular Materials and Interfaces, Sandia National Laboratories, Albuquerque, NM, USA
Ronald P. Manginell
Affiliation:
Micro-Total-Analytical Systems, Sandia National Laboratories, Albuquerque, NM, USA
Jun Liu
Affiliation:
Chemical Synthesis and Nanomaterials, Sandia National Laboratories, Albuquerque, NM, USA
Bruce C. Bunker
Affiliation:
Biomolecular Materials and Interfaces, Sandia National Laboratories, Albuquerque, NM, USA
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Abstract

The formation and nature of living materials are fundamentally different from those of synthetic materials. Synthetic materials generally have static structures, and are not capable of adapting to changing environmental conditions or stimuli. In contrast, living systems utilize energy to assemble, reconfigure, and dismantle materials in a dynamic, highly non-equilibrium fashion. The overall goal of this work is to identify and explore key strategies used by living systems to develop new types of materials in which the assembly, configuration, and disassembly can be programmed or “self-regulated” in microfluidic environments. As a model system, kinesin motor proteins and microtubule fibers have been selected as a means of directing the transport of molecular cargo, and assembly of nanostructures at synthetic interfaces. Initial work has focused on characterizing and engineering the properties of these active biomolecules for robust performance in microfluidic systems. We also have developed several strategies for functionalizing microtubule fibers with metal and semiconductor nanoparticles, and demonstrated the assembly of composite nanoscale materials. Moreover, transport of these composite assemblies has been demonstrated using energy-driven actuation by kinesin motor proteins. Current work is focused on developing mechanisms for directing the linear transport of microtubule fibers, and controlling the loading/unloading of nanoparticle cargo in microfluidic systems.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 782: Symposium A – Micro- and Nanosystems , 2003 , A1.1
Copyright
Copyright © Materials Research Society 2004

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References

REFERENCES

1. Parkinson, J., Brechet, Y., and Gordon, R., Biochim. Biophys. Acta 1452, 89–102 (1999).Google Scholar
2. Haimo, L. and Thaler, C., BioEssays 16, 727–733 (1994).Google Scholar
3. Bohm, K.J., Stracke, R., Muhlig, P., and Unger, E., Nanotechnology 12, 238–244 (2001).Google Scholar
4. Limberis, L. and Stewart, R.J., Nanotechnology 11, 47–51 (2000).Google Scholar
5. Dennis, J.R., Howard, J., and Vogel, V., Nanotechnology 10, 232–236 (1999).Google Scholar
6. Hess, H., Clemmens, J., Qin, D., Howard, J., and Vogel, V., Nano Letters 1, 235–239 (2001).Google Scholar
7. Hess, H., Clemmens, J., Matzke, C.M., Bachand, G.D., Bunker, B.C., and Vogel, V., Appl. Phys. A 75, 309–313 (2002).Google Scholar
8. Hiratsuka, Y., Tada, T., Oiwa, K., Kanayama, T., and Uyeda, T.Q.P., Biophys. J. 81, 1555–1561 (2001).Google Scholar
9. Coy, D.L., Wagenbach, M., and Howard, J., J. Biol. Chem. 274, 3667–3671 (1999).Google Scholar