Hostname: page-component-77c89778f8-7drxs Total loading time: 0 Render date: 2024-07-20T06:44:40.475Z Has data issue: false hasContentIssue false
  • English
  • Français

Dendrimer Nanocomposites as Multifunctional X-ray Contrast Agents

Published online by Cambridge University Press:  01 February 2011

Teyeb Ould Ely ,
Manju Sharma ,
Wojciech Lesniak ,
Donald L. Klippenstein ,
Barbara A. Foster  and
Lajos P. Balogh
Teyeb Ould Ely
Affiliation:
mohamedteyib.ouldely@roswellpark.org, RoswellPark Cancer Institute, Radiation Medicine, Elm and Carlton Streets, Buffalo, NY, 14263, United States, 716-845-8179, 716-845-8254
Manju Sharma
Affiliation:
sharm093@umn.edu, RoswellPark Cancer Institute, Radiation Medicine, Elm and Carlton Streets,, Buffalo, NY, 14263, United States
Wojciech Lesniak
Affiliation:
Wojciech.Lesniak@RoswellPark.org, RoswellPark Cancer Institute, Radiation Medicine, Elm and Carlton Streets, Buffalo, NY, 14263, United States
Donald L. Klippenstein
Affiliation:
Donald.Klippenstein@RoswellPark.org, RoswellPark Cancer Institute, Radiology, Elm and Carlton Streets, Buffalo, NY, 14263, United States
Barbara A. Foster
Affiliation:
Barbara.Foster@RoswellPark.org, RoswellPark Cancer Institute, Pharmacology & Therapeutics, Elm and Carlton Streets, Buffalo, NY, 14263, United States
Lajos P. Balogh
Affiliation:
Lajos.Balogh@RoswellPark.org, RoswellPark Cancer Institute, Radiation Medicine, Elm and Carlton Streets, Buffalo, NY, 14263, United States
Get access

Abstract

We synthesized dendrimer composite nanoparticles and investigated their potential for traditional X-ray imaging and Computed Tomography (CT). These new X-ray contrast agents show better contrast compared to traditional iodine-based contrast agents, and are expected to clear from the blood much slower than commercial agents, permitting longer imaging times. We have also investigated their safety profile in terms of viscosity and osmotic pressure.

Keywords

biomedicalnanostructurecomposite
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1064: Symposium PP – Quantum-Dot and Nanoparticle Bioconjugates–Tools for Sensing and Biomedical Imaging , 2007 , 1064-PP06-18
Copyright
Copyright © Materials Research Society 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

[1] Rutten, A. and Prokop, M., “Contrast agents in X-ray computed tomography and its applications in oncology,” Anti-Cancer Agents in Medicinal Chemistry, Vol. 7, pp. 307–316, 2007.Google Scholar
[2] Yordanov, A. T., Lodder, A. L., Woller, E. K., Cloninger, M. J., Patronas, N., Milenic, D., and Brechbiel, M. W., “Novel Iodinated Dendritic Nanoparticles for Computed Tomography (CT) Imaging,” Nano Letters, Vol. 2, pp. 595–599, 2002.Google Scholar
[3] Lee, A. G., Hayman, L. A., and Ross, A. W., “Neuroimaging contrast agents in ophthalmology,” Surv Ophthalmol FIELD Full Journal Title:Survey of ophthalmology, Vol. 45, pp. 237–53, 2000.Google Scholar
[4] Krause, W., “Delivery of diagnostic agents in computed tomography,” Advanced Drug Delivery Reviews, Vol. 37, pp. 159–173, 1999.Google Scholar
[5] Galperin, A., Margel, D., Baniel, J., Dank, G., Biton, H., and Margel, S., “Radiopaque iodinated polymeric nanoparticles for X-ray imaging applications,” Biomaterials, Vol. 28, pp. 4461–4468, 2007.Google Scholar
[6] Galperin, A. and Margel, S., “Synthesis and characterization of radiopaque magnetic core-shell nanoparticles for X-ray imaging applications,” J Biomed Mater Res B Appl Biomater FIELD Full Journal Title:Journal of biomedical materials research. Part B, Applied biomaterials, Vol. 83, pp. 490–8, 2007.Google Scholar
[7] Lautrou, J., Paris, D., Schaefer, M., Meyer, D., Chambon, C., and Doucet, D., “Iodinated polymers: pharmacokinetics of blood-pool imaging products,” Investigative Radiology, Vol. 25, pp. S109–S110, 1990.Google Scholar
[8] Sachse, A., Leike, J. U., Schneider, T., Wagner, S. E., Rossling, G. L., Krause, W., and Brandl, M., “Biodistribution and computed tomography blood-pool imaging properties of polyethylene glycol-coated iopromide-carrying liposomes,” Invest Radiol FIELD Full Journal Title:Investigative radiology, Vol. 32, pp. 44–50, 1997.Google Scholar
[9] Sako, M., Watanabe, H., Okuda, K., Shimizu, T., Hase, M., Hirota, S., Kono, M., and Sakamoto, K., “Studies of water-soluble iodinated starch as a new, potential contrast material,” Nippon Igaku Hoshasen Gakkai Zasshi, Vol. 47, pp. 1472–7, 1987.Google Scholar
[10] Trubetskoy, V. S., Gazelle, G. S., Wolf, G. L., and Torchilin, V. P., “Block-copolymer of polyethylene glycol and polylysine as a carrier of organic iodine. Design of long-circulating particulate contrast medium for x-ray computed tomography,” Journal of Drug Targeting, Vol. 4, pp. 381–388, 1997.Google Scholar
[11] Bogdanov, A. A. Jr., Weissleder, R., and Brady, T. J., “Long-circulating blood pool imaging agents,” Advanced Drug Delivery Reviews, Vol. 16, pp. 335–48, 1995.Google Scholar
[12] Khan, M. K., Nigavekar, S. S., Minc, L. D., M. S. T. Kariapper, Nair, B. M., Lesniak, W. G., and Balogh, L. P., “In vivo biodistribution of dendrimers and dendrimer nanocomposites-implications for cancer imaging and therapy,” Technology in Cancer Research & Treatment, Vol. 4, pp. 603–613, 2005.Google Scholar
[13] Nigavekar, S. S., Sung, L. Y., Llanes, M., El-Jawahri, A., Lawrence, T. S., Becker, C. W., Balogh, L., and Khan, M. K., “3H Dendrimer Nanoparticle Organ/Tumor Distribution,” Pharmaceutical Research, Vol. 21, pp. 476–483, 2004.Google Scholar
[14] Balogh, L., Nigavekar, S. S., Nair, B. M., Lesniak, W., Zhang, C., Sung, L. Y., Kariapper, M. S. T., El-Jawahri, A., Llanes, M., Bolton, B., Mamou, F., Tan, W., Hutson, A., Minc, L., and Khan, M. K., “Significant effect of size on the in vivo biodistribution of gold composite nanodevices in mouse tumor models,” Nanomedicine (New York, NY, United States), Vol. 3, pp. 281–296, 2007.Google Scholar
[15] Gazelle, G. S., Wolf, G. L., McIntire, G. L., Bacon, E. R., Na, G., E. F. Halpern, and J. L. Toner, “Hepatic imaging with iodinated nanoparticles: a comparison with iohexol in rabbits,” Acad Radiol FIELD Full Journal Title:Academic radiology, Vol. 2, pp. 700–4, 1995.Google Scholar
[16] Rasband, W. S., “ImageJ, U. S.,” National Institutes of Health, Bethesda, Maryland, USA, http://rsb.info.nih.gov/ij/, 1997-2007.Google Scholar
[17] Shi, X., Lesniak, W., Islam, M. T., MuNiz, M. C., Balogh, L. P., and Baker, J. R., “Comprehensive characterization of surface-functionalized poly(amidoamine) dendrimers with acetamide, hydroxyl, and carboxyl groups,” Colloids and Surfaces, A: Physicochemical and Engineering Aspects, Vol. 272, pp. 139–150, 2006.Google Scholar