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Degradation Behavior of Novel Poly(α-hydroxy acid)-Derived Polyesters

Published online by Cambridge University Press:  17 March 2011

Jay Sy ,
Xiaojun Xu ,
Anna Marie Lipski ,
Molly Stevens  and
V. Prasad Shastri
Jay Sy
Affiliation:
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104
Xiaojun Xu
Affiliation:
Department of Materials Science and Engineering, University of Pennsylvania, 3231 Walnut Street, Philadelphia, Pennsylvania 19104 Joseph Stokes Research Institute, Children's Hospital of Philadelphia, 3516 Civic Center Boulevard, Philadelphia, Pennsylvania 19104
Anna Marie Lipski
Affiliation:
Department of Materials Science and Engineering, University of Pennsylvania, 3231 Walnut Street, Philadelphia, Pennsylvania 19104
Molly Stevens
Affiliation:
Department of Materials, Imperial College London, Exhibition Road, London, SW7 2AZ, UK
V. Prasad Shastri
Affiliation:
Joseph Stokes Research Institute, Children's Hospital of Philadelphia, 3516 Civic Center Boulevard, Philadelphia, Pennsylvania 19104 Department of Materials Science and Engineering, University of Pennsylvania, 3231 Walnut Street, Philadelphia, Pennsylvania 19104Prasad.Shastri@Vanderbilt.edu
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Abstract

Due to their bioresorbable characteristics biodegradable polyesters are attractive materials for sutures, fracture fixation devices, and drug delivery systems. These polymers degrade primarily through a bulk erosion mechanism. In many instances including drug delivery and fabrication of orthopaedic devices, surface erosion is desired as it confers linearity with respect to degradation and changes in modulus. We hypothesized that surface erosion could be achieved in poly(αΏ-hydroxy acids) by tuning the lipophilicity of the system and hence the water uptake. Toward this end, we used a modular design strategy to manipulate the hydrophilic-lipophilic balance (HLB) of a polymer chain at various stages by judicious choice of building blocks. Using this novel synthetic strategy we have synthesized a library of degradable polyesters derived from poly(lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) that exhibit surface erosion behavior. Surface erosion was further verified by ultrastructure analysis of degraded polymer pellets and thin films by Scanning Electron Microscopy and tapping mode Atomic Force Microscopy respectively.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 823: Symposium W – Biological and Bioinspired Materials and Devices , 2004 , W11.10
Copyright
Copyright © Materials Research Society 2004

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