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Comparison of Dense Versus Porous Hydroxylapatite (HA) Particles for Rat Mandibular Defect Repair

Published online by Cambridge University Press:  26 February 2011

Stephen A. Fredette ,
Jacob S. Hanker ,
Bill C. Terry  and
Beverly L. Giammara
Stephen A. Fredette
Affiliation:
Dental Research Center and Department of Oral & Maxillofacial Surgery, University of North Carolina, Chapel Hill, North Carolina 27514
Jacob S. Hanker
Affiliation:
Dental Research Center and Department of Oral & Maxillofacial Surgery, University of North Carolina, Chapel Hill, North Carolina 27514
Bill C. Terry
Affiliation:
Dental Research Center and Department of Oral & Maxillofacial Surgery, University of North Carolina, Chapel Hill, North Carolina 27514
Beverly L. Giammara
Affiliation:
Graduate Programs and Research, University of Louisville, Louisville, Kentucky 40292.
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Abstract

Repair was compared in 4.4mm experimental rat mandibular ramus defects implanted with dense or porous HA particles with or without a plaster binder. Animals were sacrificed 6 months postimplantation. Specimens underwent gross, radiographic, histochemical and X-ray microanalytical examination. Gross and radiographic examinations showed good particle containment or retention only in defects filled with implants containing plaster. Only porous HA/plaster filled defects showed bone formation throughout the implant when examined histochemically by the PATS reaction and by X-ray microanalysis. They also showed greater radiographic opacity compared to dense HA/plaster implants. Only porous HA/plaster implants showed macroscopic bone formation. Examination of defects filled with porous HA/plaster or porous HA alone by the PATS reaction showed new cancellous bone around, and through the pores of, retained particles. The dense HA/plaster implants showed some new bone around the rims of the defects with only occasional bony incorporation of an HA particle. Dense particles in other areas showed only soft tissue encapsulation. Defects implanted with dense HA without plaster showed no new bone formation but retained particles were incorporated by fibrovascular tissue.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 110: Symposium M – Biomedical Materials and Devices , 1987 , 233
Copyright
Copyright © Materials Research Society 1988

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