Hostname: page-component-8448b6f56d-wq2xx Total loading time: 0 Render date: 2024-04-23T07:59:21.559Z Has data issue: false hasContentIssue false
  • English
  • Français

Bioactive Polypyrrole Thin Films with Conductimetric Response to Analyte

Published online by Cambridge University Press:  10 February 2011

A. Guiseppi-Elie ,
J. M. Tour ,
D. L. Allarat  and
N. F. Sheppard Jr.
A. Guiseppi-Elie
Affiliation:
Research and Development Department, Aai-Abtech, Yardley, PA 19067 Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208
J. M. Tour
Affiliation:
Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208
D. L. Allarat
Affiliation:
Materials Research Institute, The Pennsylvania State University, University Park, PA 16802
N. F. Sheppard Jr.
Affiliation:
Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21218
Get access

Abstract

Thin films of electroconductive poly[pyrrole-co-3−(1−pyrrolyl)propionic acid] were prepared by electropolymerization onto 3-aminopropyltrimethoxysilane modified and 3−(1−pyrrolyl)propionic acid derivatized interdigitated microsensor electrode (IME) arrays. The ω−(1−pyrrolyl) moiety on the surface of the device provides for specific adhesion of the polymer film to the device and the (N-pyrrolyl)propionic acid moiety on the polymer backbone provides for covalent attachment of bioactive molecules, such as biotin and urease, to the polymer surface. The immobilized, bioactive urease produces an ON/OFF conductimetric response traceable to analyte concentration.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 413: Symposium W – Electrical, Optical, and Magnetic Properties of Organic Solid State Materials III , 1995 , 439
Copyright
Copyright © Materials Research Society 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Ivaska, A., Electroanalysis 3:247 (1991); C. E. D. Chidsey and R. W. Murray, Science 231:25 (1986); R. A. Hillman in Electrochemical Science and Technology of Polymers-I, edited by R. G. Linford (Elsevier, New York, 1987) p. 241; G. K. Chandler and D. Pletcher in Electrochemistry 10 edited by D. Pletcher (Royal Society of Chemistry, London, 1993) p. 117; P. N. Bartlett and J. M. Cooper, J. Electroanal. Chem. 362:1 (1993).Google Scholar
2. Nishizawa, M., Matsue, T. and Uchida, I., Anal. Chem., 64, 2642 (1992).Google Scholar
3. Guiseppi-Elie, A., Wilson, A. M., Tour, J. M., Brockmann, T. W., Zhang, P. and Allara, D. L., Langmuir 11:1768 (1995).Google Scholar
4. Zaretsky, M. C., Mouyad, L., and Melcher, J. R., IEEE Trans. Elec. Ins., 23(6), 897 (1988); N. F. Sheppard, Jr., R. C. Tucker and C. Wu, Anal. Chem., 65(9), 1199 (1993).Google Scholar
5. Jr., N. F. Sheppard, Mears, D. J. and Guiseppi-Elie, A., Biosen. Bioelectron. (in press).Google Scholar