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Aqueous Ferrofluid of Citric Acid Coated Magnetite Particles

Published online by Cambridge University Press:  01 February 2011

A. Goodarzi
Affiliation:
Department of Chemical and Biological Engineering and Institute for Lasers, Photonics and Biophotonics, University at Buffalo (SUNY), Buffalo, NY, 14260
Y. Sahoo
Affiliation:
Department of Chemistry and Institute for Lasers, Photonics and Biophotonics, University at Buffalo (SUNY), Buffalo, NY, 14260
M. T. Swihart
Affiliation:
Department of Chemical and Biological Engineering and Institute for Lasers, Photonics and Biophotonics, University at Buffalo (SUNY), Buffalo, NY, 14260
P. N. Prasad
Affiliation:
Department of Chemistry and Institute for Lasers, Photonics and Biophotonics, University at Buffalo (SUNY), Buffalo, NY, 14260
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Abstract

Magnetic nanoparticles have found application in medical diagnostics such as magnetic resonance imaging and therapies such as cancer treatment. In these applications, it is imperative to have a biocompatible solvent such as water at optimum pH for possible bio-ingestion. In the present work, a synthetic methodology has been developed to get a well-dispersed and homogeneous aqueous suspension of Fe3O4 nanoparticles in the size range of 8–10 nm. The surface functionalization of the particles is provided by citric acid. The particles have been characterized using transmission electron microscopy, magnetization measurements with a superconducting quantum interference device, FTIR spectroscopy (for surfactant binding sites), thermogravimetric studies (for strength of surfactant binding), and x-ray photoelectron spectroscopy and x-ray diffraction (for composition and phase information). The carboxylate functionality on the surface provides an avenue for further surface modification with fluorescent dyes, hormone linkers etc for possible cell-binding, bioimaging, tracking, and targeting.

Type
Research Article
Copyright
Copyright © Materials Research Society 2004

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