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Aerosol-Based Direct-Write of Biological Materials for Biomedical Applications

Published online by Cambridge University Press:  17 March 2011

Gregory J. Marquez ,
Michael J. Renn  and
W. Doyle Miller
Gregory J. Marquez
Affiliation:
Optomec, Inc. 3911 Singer NE, Albuquerque, NM 87109, gmarquez@optomec.com
Michael J. Renn
Affiliation:
Optomec, Inc. 3911 Singer NE, Albuquerque, NM 87109, gmarquez@optomec.com
W. Doyle Miller
Affiliation:
Optomec, Inc. 3911 Singer NE, Albuquerque, NM 87109, gmarquez@optomec.com
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Abstract

Applying life sciences and engineering principles to the study of cells and engineered tissue has resulted in various successes. These endeavors are poised towards development of functional neo-organs used as native tissue substitutes. Concurrent with this goal, research arenas are directed in the general areas of biocompatible polymer scaffolds, biomimmetic extracellular matrices, control of stem cell differentiation, biomolecule signaling, and directed material delivery. Optomec Inc. is developing an aerosol-based direct-write process for deposition of biological materials into three dimensional, micron-scale patterns. The process uses pneumatic atomization to produce aerosol droplets of proteinacious colloidal dispersions and whole cell suspensions. The droplets are entrained in an air stream and deposited with a proprietary deposition tool. The biological materials can be seeded into three dimensional polymer scaffolds and various substrate surfaces. Optomec's direct write process has applicability to the additive fabrication of engineered tissue. Other applications of the direct write tool include rapid prototyping of analytical biosensors, hybrid BioMEMS, and bio-chip microarray devices.

Keywords

tissue engineeringcell-aerosolizationbiomoleculemicropatterningdirect-writebiological material deposition
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 698: Symposia Q/EE Electroative Polymers and Rapid Prototyping , 2001 , Q5.2.1
Copyright
Copyright © Materials Research Society 2002

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References

REFERENCES

1. Renn, M.J. et al., in “Introduction to Direct-Write Technologies for Rapid Prototyping,” In Direct-Write Technologies for Rapid Prototyping Applications: Sensors, Electronics, and Integrated Power Sources, Edited by Pique, A., Chrisey, D. B., (Academic Press, San Diego, 2002) p. 475–492.Google Scholar
2. Miller, D., Renn, M.J., King, B., Essien, M., Maskless Mesoscale Materials Deposition, HDI 4(9), p. 20–2.Sept. 2001.Google Scholar
3. Chrisey, D.B., Pique, A., in “Introduction to Direct-Write Technologies for Rapid Prototyping,” In Direct-Write Technologies for Rapid Prototyping Applications: Sensors, Electronics, and Integrated Power Sources, Edited by Pique, A., Chrisey, D. B., (Academic Press, San Diego, 2002) p. 1–13.Google Scholar
4. Simon, F., Hermel, G., Lunkwitz, D., Werner, C., Eichhorn, K., Jacobasch, H.-J., Macromol. Sym. 103, 243–257 (1996).Google Scholar
5. Bhattacharjee, Y., Ligand Chip Helps Manipulate Cells, Science 290 (5496) 2000, p. 1477–1478.Google Scholar
6. Jung, D.R. et al, Topographical and physicochemical modification of material surface to enable patterning of living cells, (2001) Crit. Rev. Biotech 21, 111.Google Scholar
7. Odde, D. and Renn, M.J., Laser-Guided Direct-Writing for applications in Biotechnology, Trends in Biotechnology, 1999. 17: p. 385–389.Google Scholar
8. Odde, D. and Renn, M.J., Laser-Guided Direct-Writing of Living Cells (2000) Biotechnol. Bioeng. 67, 312.Google Scholar
9. Chrisey, D.B., et al., Laser Direct Writing Builds Biostructures, Laser Focus World, 2000. p. 113–116.Google Scholar
10. Niklason, L.E., et al., Functional arteries grown in vitro. Science, 1999: 284: 389–544.Google Scholar
11. Cooley, P.W., et al., Ink-Jet deposited microspot arrays of DNA and other bioactive molecules. In Methods in Molecular Biology, Vol. 170, Rampal, J.B., Ed., 2001, Humana, Totowana, NJ.Google Scholar
12. Wu, P.K., et al., The deposition, structure, pattern deposition, and activity of biomaterial thin films by MAPLE direct write, Thin Solid Film, in Press.Google Scholar
13. McGill, R.A., Ringeisen, B., Wu, P.K., The Role of Direct Writing for Chemical and Biological Materials: Commercial and Military Sensing Applications,” In Direct-Write Technologies for Rapid Prototyping Applications: Sensors, Electronics, and Integrated Power Sources, A. Pique, D. Chrisey, B., Eds. 2002, Academic Press, p. 475–492.Google Scholar