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The Sustained Release of Galardin and Taxol from Gelatin Chondroitin Sulfate Coacervate Films

Published online by Cambridge University Press:  21 February 2011

Phillip F. Heller
Affiliation:
Laboratory of Cardiovascular Sciences, Gerontology Research Center, Baltimore, Maryland 21214.
G. Mark Jenkins
Affiliation:
Laboratory of Cardiovascular Sciences, Gerontology Research Center, Baltimore, Maryland 21214.
Linda Cheng
Affiliation:
Laboratory of Cardiovascular Sciences, Gerontology Research Center, Baltimore, Maryland 21214.
Kam Leong
Affiliation:
Johns Hopkins University School of Medicine, Baltimore MD.
Wen Shao
Affiliation:
Johns Hopkins University School of Medicine, Baltimore MD.
Jeffrey Brinker
Affiliation:
Johns Hopkins University School of Medicine, Baltimore MD.
Earl Hope
Affiliation:
Johns Hopkins University School of Medicine, Baltimore MD.
Cynthia Nater
Affiliation:
Laboratory of Cardiovascular Sciences, Gerontology Research Center, Baltimore, Maryland 21214.
Edward Lakatta
Affiliation:
Laboratory of Cardiovascular Sciences, Gerontology Research Center, Baltimore, Maryland 21214.
Jeffrey P. Froehlich
Affiliation:
Laboratory of Cardiovascular Sciences, Gerontology Research Center, Baltimore, Maryland 21214.
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Extract

Coronary artery atherosclerosis is the leading cause of death in the United States. Restenosis following percutaneous transluminal balloon angioplasty (PTCA) remains the limiting factor in the use of this treatment for coronary artery disease. Restenosis occurs in 30% of patients within 6 months. The restenotic lesion is a fibroproliferative response with resulting smooth muscle cell migration, proliferation and extracellular matrix production. Despite a decade of research there is no effective strategy for preventing restenosis in man.

Type
Research Article
Copyright
Copyright © Materials Research Society 1995

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References

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The Sustained Release of Galardin and Taxol from Gelatin Chondroitin Sulfate Coacervate Films
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