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Poly(L-Lactic Acid-Co-Aspartic Acid): Interactive Polymers for Tissue Engineering

Published online by Cambridge University Press:  21 February 2011

Jeffrey S. Hrkach
Affiliation:
MIT, Dept. of Chemical Engineering, E25-342, Cambridge, MA 02139
Jean Ou
Affiliation:
Harvard University, Dept. of Chemistry, Cambridge, MA 02138
Noah Lotan
Affiliation:
Technion Israel Institute of Technology, Dept. of Biomedical Engineering, Haifa, Israel 32000
Robert Langer
Affiliation:
MIT, Dept. of Chemical Engineering, E25-342, Cambridge, MA 02139
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Abstract

One of the challenges in the field of tissue engineering is the development of optimal materials for use as scaffolds to support cell growth and tissue development. For this purpose, we are developing synthetic, biodegradable polymers with functional sites that provide the opportunity to covalently attach biologically active molecules to the polymers, so they can predictably interact with cells in a favorable manner to enhance cell attachment and growth. The preparation of poly(L-lactic acid-co-aspartic acid) comb-like graft copolymers from poly(L-lactic acid-co-β-benzyl-L-aspartate), and the casting of polymer films by solvent evaporation were carried out.

Type
Research Article
Copyright
Copyright © Materials Research Society 1995

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References

(1) Langer, R. and Vacanti, J. P., Science 260, 920 (1993).CrossRefGoogle Scholar
(2) Freed, L. E., Vunjak-Novakovic, G., Biron, R. J., Eagles, D. B., Lesnoy, D. B., Barlow, S. K., Langer, R., Bio/Technology 12, 689 (1994).Google Scholar
(3) Mooney, D. J., Park, S., Kaufmann, P. M., Sano, K., McNamara, K., Vacanti, J. P., Langer, R., J. Biomed. Mater. Res., in press.Google Scholar
(4) Barrera, D. A., Zylstra, E., Lansbury, P. T. Jr., Langer, R., J. Am. Chem. Soc. 115, 11010 (1993).CrossRefGoogle Scholar
(5) Hrkach, J. S., Ou, J., Lotan, N., Langer, R., Macromolecules, in press.Google Scholar
(6) Hrkach, J. S., Ou, J., Lotan, N., Langer, R., ACS Symposium Series, in press.Google Scholar
(7) GPC was not used to determine the molecular weights of the graft copolymers, but only to detect the presence of a single polymer species. The use of linear polystyrene standards will result in inaccurate calculation of the molecular weights of the branched graft copolymers.Google Scholar
(8) Barrera, D. A., Ph.D. Thesis, Massachusetts Institute of Technology, 1994.Google Scholar

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