Hostname: page-component-8448b6f56d-c4f8m Total loading time: 0 Render date: 2024-04-21T21:49:12.972Z Has data issue: false hasContentIssue false

Nanostructured Ceramic and Ceramic-Polymer Composites as Dual Functional Interface for Bioresorbable Metallic Implants

Published online by Cambridge University Press:  02 April 2014

Ian Johnson
Affiliation:
Department of Bioengineering, University of California, Riverside, CA 92521, U.S.A.
Qiaomu Tian
Affiliation:
Department of Bioengineering, University of California, Riverside, CA 92521, U.S.A.
Huinan Liu
Affiliation:
Department of Bioengineering, University of California, Riverside, CA 92521, U.S.A. Materials Science and Engineering, University of California, Riverside, CA 92521, U.S.A.
Get access

Abstract

Millions of medical implants and devices (e.g., screws, plates, and pins) are used each year worldwide in surgery, and traditionally the components have been limited to permanent metals (e.g., stainless steel, titanium alloys) and polyester-based absorbable polymers. Because of clinical problems associated with these traditional materials, a novel class of biodegradable metallic materials, i.e., magnesium-based alloys, attracted great attention and clinical interests. Magnesium (Mg) is particularly attractive for load-bearing orthopedic applications because it has comparable modulus and strength to cortical bone. Controlling the interface of Mg with the biological environment, however, is the key challenge that currently limits this biodegradable metal for broad applications in medical devices and implants. This paper will particularly focus on creating nanostructured interface between the biodegradable metallic implant and surrounding tissue for the dual purposes of (1) mediating the degradation of the metallic implants and (2) simultaneously enhancing bone tissue regeneration and integration. Nanophase hydroxyapatite (nHA) is an excellent candidate as a coating material due to its osteoconductivity that has been widely reported. Applying nHA coatings or nHA containing composite coatings on Mg alloys is therefore promising in serving the needed dual functions. The composite of nHA and poly(lactic-co-glycolic acid) (PLGA) as a dual functional interface provides additional benefits for medical implant applications. Specifically, the polymer phase promotes interfacial adhesion between the nHA and Mg, and the degradation products of PLGA and Mg neutralize each other. Our results indicate that nHA and nHA/PLGA coatings slow down Mg degradation rate and enhance adhesion of bone marrow stromal cells, thus promising as the next-generation multifunctional implant materials. Further optimization of the coatings and their interfacial properties are still needed to bring them into clinical applications.

Type
Articles
Copyright
Copyright © Materials Research Society 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Zhang, Y, Ren, L, Li, M, Lin, X, Zhao, HF, Yang, K. Preliminary Study on Cytotoxic Effect of Biodegradation of Magnesium on Cancer Cells. Journal of Materials Science & Technology 2012;28(9):769772.CrossRefGoogle Scholar
Saver, JL, Kidwell, C, Eckstein, M, Starkman, S, Investigators F-MPT. Prehospital neuroprotective therapy for acute stroke - Results of the field administration of stroke therapy-magnesium (FAST-MAG) pilot trial. Stroke 2004;35(5):E106E108.CrossRefGoogle ScholarPubMed
Lock, JY, Wyatt, E, Upadhyayula, S, Whall, A, Nunez, V, Vullev, VI, Liu, H. Degradation and antibacterial properties of magnesium alloys in artificial urine for potential resorbable ureteral stent applications. Journal of Biomedical Materials Research Part A 2013.Google ScholarPubMed
Nan, M, Yangmei, C, Bangcheng, Y. Magnesium metal - a potential biomaterial with anti-bone cancer properties. Journal of Biomedical Materials Research Part A 2013.Google ScholarPubMed
Park, J-W, Kim, Y-J, Jang, J-H, Song, H. Osteoblast response to magnesium ion-incorporated nanoporous titanium oxide surfaces. Clinical Oral Implants Research 2010;21(11):12781287.CrossRefGoogle ScholarPubMed
Janning, C, Willbold, E, Vogt, C, Nellesen, J, Meyer-Lindenberg, A, Windhagen, H, Thorey, F, Witte, F. Magnesium hydroxide temporarily enhancing osteoblast activity and decreasing the osteoclast number in peri-implant bone remodelling. Acta Biomaterialia 2010;6(5):1861–8.CrossRefGoogle ScholarPubMed
Brar, HS, Platt, MO, Sarntinoranont, M, Martin, PI, Manuel, MV. Magnesium as a biodegradable and bioabsorbable material for medical implants. Jom 2009;61(9):3134.CrossRefGoogle Scholar
Erdmann, N, Angrisani, N, Reifenrath, J, Lucas, A, Thorey, F, Bormann, D, Meyer-Lindenberg, A. Biomechanical testing and degradation analysis of MgCa0.8 alloy screws: A comparative in vivo study in rabbits. Acta Biomaterialia 2011;7(3):14211428.CrossRefGoogle ScholarPubMed
Witte, F. The history of biodegradable magnesium implants: A review. Acta Biomaterialia 2010;6(5):16801692.CrossRefGoogle ScholarPubMed
Song, G, Atrens, A. Understanding Magnesium Corrosion—A Framework for Improved Alloy Performance. Advanced Engineering Materials 2003;5(12):837858.CrossRefGoogle Scholar
Iskandar, ME, Aslani, A, Liu, HN. The effects of nanostructured hydroxyapatite coating on the biodegradation and cytocompatibility of magnesium implants. Journal of Biomedical Materials Research Part A 2013;101A(8):23402354.CrossRefGoogle Scholar
Johnson, I, Akari, K, Liu, H. Nanostructured Hydroxyapatite/Poly(lactic-co-glycolic acid) (PLGA) Composite Coating for Controlling Magnesium Degradation in Simulated Body Fluid. Nanotechnology 2013;24(37).CrossRefGoogle ScholarPubMed
Johnson, I, Liu, HN. A Study on Factors Affecting the Degradation of Magnesium and a Magnesium-Yttrium Alloy for Biomedical Applications. PLoS One 2013;8(6).Google Scholar
Hing, KA, Wilson, LE, Buckland, T. Comparative performance of three ceramic bone graft substitutes. Spine Journal 2007;7(4):475490.CrossRefGoogle ScholarPubMed
Sung, HJ, Meredith, C, Johnson, C, Galis, ZS. The effect of scaffold degradation rate on three-dimensional cell growth and angiogenesis. Biomaterials 2004;25(26):5735–42.CrossRefGoogle ScholarPubMed
Guan, RG, Johnson, I, Cui, T, Zhao, T, Zhao, ZY, Li, X, Liu, HN. Electrodeposition of hydroxyapatite coating on Mg-4.0Zn-1.0Ca-0.6Zr alloy and in vitro evaluation of degradation, hemolysis, and cytotoxicity. Journal of Biomedical Materials Research Part A 2012;100A(4):9991015.CrossRefGoogle Scholar
Ergun, C, Liu, HN, Halloran, JW, Webster, TJ. Increased osteoblast adhesion on nanograined hydroxyapatite and tricalcium phosphate containing calcium titanate. Journal of Biomedical Materials Research Part A 2007;80A(4):990997.CrossRefGoogle Scholar
Evans, AG, Crumley, GB, Demaray, RE. On the Mechanical-Behavior of Brittle Coatings and Layers. Oxidation of Metals 1983;20(5-6):193216.CrossRefGoogle Scholar
Wei, M, Ruys, AJ, Swain, MV, Kim, SH, Milthorpe, BK, Sorrell, CC. Interfacial bond strength of electrophoretically deposited hydroxyapatite coatings on metals. Journal of Materials Science-Materials in Medicine 1999;10(7):401409.CrossRefGoogle ScholarPubMed
Wang, BC, Chang, E, Lee, TM, Yang, CY. Changes in Phases and Crystallinity of Plasma-Sprayed Hydroxyapatite Coatings under Heat-Treatment - a Quantitative Study. Journal of Biomedical Materials Research 1995;29(12):14831492.CrossRefGoogle ScholarPubMed
Sato, M, Sambito, MA, Aslani, A, Kalkhoran, NM, Slamovich, EB, Webster, TJ. Increased osteoblast functions on undoped and yttrium-doped nanocrystalline hydroxyapatite coatings on titanium. Biomaterials 2006;27(11):23582369.CrossRefGoogle Scholar
Lock, J, Nguyen, TY, Liu, HN. Nanophase hydroxyapatite and poly(lactide-co-glycolide) composites promote human mesenchymal stem cell adhesion and osteogenic differentiation in vitro. Journal of Materials Science-Materials in Medicine 2012;23(10):25432552.CrossRefGoogle ScholarPubMed
Lock, J, Liu, HN. Nanomaterials enhance osteogenic differentiation of human mesenchymal stem cells similar to a short peptide of BMP-7. International Journal of Nanomedicine 2011;6:27692777.Google ScholarPubMed
Ravichandran, R, Ng, CCH, Liao, S, Pliszka, D, Raghunath, M, Ramakrishna, S, Chan, CK. Biomimetic surface modification of titanium surfaces for early cell capture by advanced electrospinning. Biomedical Materials 2012;7(1).CrossRefGoogle ScholarPubMed
Liu, H, Webster, T. Enhanced biological and mechanical properties of well-dispersed nanophase ceramics in polymer composites: from 2D to 3D printed structures. Materials Science and Engineering 2011;31(2):7789.CrossRefGoogle Scholar
Zhang, YJ, Zhang, GZ, Wei, M. Controlling the Biodegradation Rate of Magnesium Using Biomimetic Apatite Coating. Journal of Biomedical Materials Research Part B-Applied Biomaterials 2009;89B(2):408414.CrossRefGoogle Scholar
Karageorgiou, V, Kaplan, D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 2005;26(27):5474–91.CrossRefGoogle ScholarPubMed