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Matrix Assisted Pulsed Laser Evaporation of Dexamethasone Thin Films

Published online by Cambridge University Press:  01 February 2011

Timothy M. Patz
Affiliation:
Bioengineering Program and School of Material Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA
Anand Doraiswamy
Affiliation:
Bioengineering Program and School of Material Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA
Roger J. Narayan
Affiliation:
Bioengineering Program and School of Material Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA
Nicola Menegazzo
Affiliation:
Georgia Institute of Technology, School of Chemistry and Biochemistry, Atlanta - GA -30332-0400, USA
Christine Kranz
Affiliation:
Georgia Institute of Technology, School of Chemistry and Biochemistry, Atlanta - GA -30332-0400, USA
Boris Mizakoff
Affiliation:
Georgia Institute of Technology, School of Chemistry and Biochemistry, Atlanta - GA -30332-0400, USA
Yinghui Zhong
Affiliation:
Coulter Department of Biomedical Engineering, Georgia Institute of Technology, NW, Atlanta, GA, USA
Ravi Bellamkonda
Affiliation:
Coulter Department of Biomedical Engineering, Georgia Institute of Technology, NW, Atlanta, GA, USA
Rohit Modi
Affiliation:
US Naval Research Laboratory, Washington, DC, USA
Douglas B. Chrisey
Affiliation:
US Naval Research Laboratory, Washington, DC, USA
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Abstract

We have demonstrated deposition of dexamethasone thin films via matrix assisted pulsed laser evaporation (MAPLE). Infrared analysis revealed that dexamethasone thin films deposited by MAPLE and by drop casting had a similar absorbance spectra. AFM imaging of the MAPLE-deposited dexamethasone thin film revealed 2–10 μm punctuate ring-like structures. Deposited dexamethasone was tested for positive bioactivity by treating primary microglia cells with lipopolysacchride and measuring nitric oxide (NO) production. The successful deposition of dexamethasone thin films can be used on neural implants to prevent tissue injury and inflammatory response.

Type
Research Article
Copyright
Copyright © Materials Research Society 2005

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