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Electrospun Gelatin/Hydroxyapatite Nanocomposite Scaffolds for Bone Tissue Engineering

Published online by Cambridge University Press:  01 February 2011

Shane Catledge
Affiliation:
catledge@uab.edu, University of Alabama at Birmingham, Physics, 1300 University Blvd., 310 Campbell Hall, Birmingham, AL, 35294-1170, United States
Parul Tyagi
Affiliation:
ptyagi@uab.edu, University of Alabama at Birmingham, Physics, 1300 University Blvd., 310 Campbell Hall, Birmingham, AL, 35294-1170, United States
Mark Koopman
Affiliation:
mkoopman@uab.edu, University of Alabama at Birmingham, Materials Science and Engineering, BEC 1150 10th Ave. South, Birmingham, AL, 35294-4461, United States
Andrei Stanishevsky
Affiliation:
astan@uab.edu, University of Alabama at Birmingham, Physics, 1300 University Blvd., 310 Campbell Hall, Birmingham, AL, 35294-1170, United States
Yogesh K. Vohra
Affiliation:
ykvohra@uab.edu, University of Alabama at Birmingham, Physics, 1300 University Blvd., 310 Campbell Hall, Birmingham, AL, 35294-1170, United States
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Abstract

Electrospun composite scaffolds were prepared by mixing gelatin with nanoparticles of hydroxyapatite (nanoHA) in 2,2,2-trifluoroethanol (TFE) solution. The fibrous composite scaffolds with nanoHA content from 0 to 40 wt% were compared in terms of structure and morphology via x-ray diffraction (XRD) and scanning electron microscopy (SEM). Results show that dispersion of nanoHA in the scaffolds is uniform for 0%, 10%, 20%, and 30% nanoHA content, but significant nanoHA agglomeration can be observed for scaffolds with 40% nanoHA. In order to study the effect of nanoHA content on mechanical properties at the nanoscale level, the fibrous scaffolds were pressed into dense pellets and tested by nanoindentation to determine Young's modulus. Young's modulus was found to increase linearly with nanoHA content, reaching unexpectedly high values of 10.2 ± 0.8 GPa. Results are compared with other polymer/HA composites including those made with polycaprolactone or collagen.

Type
Research Article
Copyright
Copyright © Materials Research Society 2008

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