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Development of a Single Molecular Tunnel-Current Identification method For Electrical Genome Sequencing
Published online by Cambridge University Press: 09 February 2015
We developed a tunnel-current based identification method by using nano-gap integrated devices. We performed electrical measurements for mono-nucleotide and oligo-nucleotide during its translocation of molecules between the nano-gap. Based on this determined electrical conductivity for single-nucleotides, we electrically identify the base-type in oligonucleotides, and found that this time-profiles represents the molecular translocation behaviors inside nano-gap. This method could be a promising for an electrical nucleotide sequencing methodology with label-free, high-speed, and low-cost.
- MRS Online Proceedings Library (OPL) , Volume 1724: Symposium H – Micro/Nano Engineering and Devices for Molecular and Cellular Manipulation, Simulation and Analysis , 2014 , mrsf14-1724-h06-05
- Copyright © Materials Research Society 2015