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Preparation of graphene oxide-reinforced calcium phosphate/calcium sulfate/methylcellulose-based injectable bone substitutes

Published online by Cambridge University Press:  13 September 2019

Öznur Demir Oğuz Open the ORCID record for Öznur Demir Oğuz [Opens in a new window]  and
Duygu Ege Open the ORCID record for Duygu Ege [Opens in a new window]
Öznur Demir Oğuz
Affiliation:
Boğaziçi University, Institute of Biomedical Engineering, Istanbul34684, Turkey
Duygu Ege*
Affiliation:
Boğaziçi University, Institute of Biomedical Engineering, Istanbul34684, Turkey
*
Address all correspondence to Duygu Ege at duygu.ege@boun.edu.tr
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Abstract

In this study, an injectable bone substitute (IBS) was produced by mixing a liquid and powder phase. The liquid phase consisted of 8 wt% methylcellulose (MC), 2.5% gelatin, and different amounts of graphene oxide (GO). The powder phase was composed of tetracalcium phosphate (TTCP), dicalcium phosphate dihydrate (DCPD), and calcium sulfate dihydrate (CSD). The results showed that 1 and 1.5 wt% GO added IBS samples showed higher stability, injectability, rheological properties, and biocompatibility than the other GO added IBS samples. GO addition significantly decreased the setting time, but it did not significantly affect the compressive strength of the samples.

Type
Research Letters
Information
MRS Communications , Volume 9 , Issue 4 , December 2019 , pp. 1174 - 1180
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Copyright
Copyright © The Author(s) 2019

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