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Europium(III)-induced water-soluble nano-aggregates of hyaluronic acid and chitosan: structure and fluorescence

Published online by Cambridge University Press:  25 June 2018

Junlan Guo ,
Jianguo Tang ,
Jing Wang 1 ,
Sui Mao ,
Haidong Li ,
Yao Wang ,
Jin Liu ,
Jing Wang 2 ,
Yanxin Wang  and
Linjun Huang
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Junlan Guo
Affiliation:
Institute of Hybrid Materials, National Center of International Joint Research for Hybrid Materials Technology, National Base of International Sci. & Technology Cooperation on Hybrid Materials, Qingdao University, 308 Ningxia Road, Qingdao 266071, People's Republic of China
Jianguo Tang*
Affiliation:
Institute of Hybrid Materials, National Center of International Joint Research for Hybrid Materials Technology, National Base of International Sci. & Technology Cooperation on Hybrid Materials, Qingdao University, 308 Ningxia Road, Qingdao 266071, People's Republic of China
Jing Wang 1
Affiliation:
Institute of Hybrid Materials, National Center of International Joint Research for Hybrid Materials Technology, National Base of International Sci. & Technology Cooperation on Hybrid Materials, Qingdao University, 308 Ningxia Road, Qingdao 266071, People's Republic of China
Sui Mao
Affiliation:
Institute of Hybrid Materials, National Center of International Joint Research for Hybrid Materials Technology, National Base of International Sci. & Technology Cooperation on Hybrid Materials, Qingdao University, 308 Ningxia Road, Qingdao 266071, People's Republic of China
Haidong Li
Affiliation:
Institute of Hybrid Materials, National Center of International Joint Research for Hybrid Materials Technology, National Base of International Sci. & Technology Cooperation on Hybrid Materials, Qingdao University, 308 Ningxia Road, Qingdao 266071, People's Republic of China
Yao Wang
Affiliation:
Institute of Hybrid Materials, National Center of International Joint Research for Hybrid Materials Technology, National Base of International Sci. & Technology Cooperation on Hybrid Materials, Qingdao University, 308 Ningxia Road, Qingdao 266071, People's Republic of China
Jin Liu
Affiliation:
Institute of Hybrid Materials, National Center of International Joint Research for Hybrid Materials Technology, National Base of International Sci. & Technology Cooperation on Hybrid Materials, Qingdao University, 308 Ningxia Road, Qingdao 266071, People's Republic of China
Jing Wang 2
Affiliation:
Institute of Hybrid Materials, National Center of International Joint Research for Hybrid Materials Technology, National Base of International Sci. & Technology Cooperation on Hybrid Materials, Qingdao University, 308 Ningxia Road, Qingdao 266071, People's Republic of China
Yanxin Wang
Affiliation:
Institute of Hybrid Materials, National Center of International Joint Research for Hybrid Materials Technology, National Base of International Sci. & Technology Cooperation on Hybrid Materials, Qingdao University, 308 Ningxia Road, Qingdao 266071, People's Republic of China
Linjun Huang
Affiliation:
Institute of Hybrid Materials, National Center of International Joint Research for Hybrid Materials Technology, National Base of International Sci. & Technology Cooperation on Hybrid Materials, Qingdao University, 308 Ningxia Road, Qingdao 266071, People's Republic of China
Matt J. Kipper*
Affiliation:
Department of Chemical and Biological Engineering, Colorado State University, Fort Collins, Colorado 80523, USA
Laurence A. Belfiore*
Affiliation:
Department of Chemical and Biological Engineering, Colorado State University, Fort Collins, Colorado 80523, USA
*
Address all correspondence to Jianguo Tang at jianguotangde@hotmail.com, Matt J. Kipper at Matthew.Kipper@ColoState.EDU, and Laurence A. Belfiore at Laurence.Belfiore@ColoState.EDU
Address all correspondence to Jianguo Tang at jianguotangde@hotmail.com, Matt J. Kipper at Matthew.Kipper@ColoState.EDU, and Laurence A. Belfiore at Laurence.Belfiore@ColoState.EDU
Address all correspondence to Jianguo Tang at jianguotangde@hotmail.com, Matt J. Kipper at Matthew.Kipper@ColoState.EDU, and Laurence A. Belfiore at Laurence.Belfiore@ColoState.EDU
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Abstract

This paper presents new water-soluble bio-polyelectrolyte-based nanoparticles, formed from lanthanide-induced polysaccharide aggregates (LIPAs). These new nano-aggregates are formed by coordinating a photoluminescent lanthanide–ligand complex to a single polyelectrolyte [i.e. polyanionic hyaluronic acid (HA)] or to two oppositely charged polyelectrolytes [i.e. HA and polycationic chitosan (CHI)]. We demonstrate that photoluminescent Eu3+–ligand complexes, which are dispersed homogeneously in aqueous solution by the association with water-soluble HA. The polysaccharide supermolecular assembly can be tuned to obtain nanoparticles of different sizes and surface charges. The preparation of stable and water-soluble lanthanide complexes via Eu3+–LIPAs opens opportunities for use of luminescent lanthanides in aqueous environments, for biosensing and bioimaging applications.

Type
Research Letters
Information
MRS Communications , Volume 8 , Issue 3 , September 2018 , pp. 1224 - 1229
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Copyright
Copyright © Materials Research Society 2018 

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