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Prevention of Candida biofilm formation over polystyrene by plasma polymerization technique

Published online by Cambridge University Press:  15 October 2020

Gizem Kaleli-Can
Department of Biomedical Engineering, İzmir Democracy University, İzmir 35140, Turkey
Elvan Hortaç-İştar
Department of Medical Microbiology, Faculty of Medicine, Başkent University, Ankara 06790, Turkey
Hatice Ferda Özgüzar
Biomedical Engineering Division, Graduate School of Science and Technology, TOBB University of Economics and Technology, Ankara 06560, Turkey
Mehmet Mutlu
Department of Mechanical Engineering, Ostim Technical University, Ankara 06374, Turkey
Hasan Cenk Mirza
Department of Medical Microbiology, Faculty of Medicine, Başkent University, Ankara 06790, Turkey
Ahmet Başustaoğlu
Department of Medical Microbiology, Faculty of Medicine, Başkent University, Ankara 06790, Turkey
Julide Sedef Göçmen
Department of Medical Microbiology, Faculty of Medicine, TOBB University of Economics and Technology, Ankara 06560, Turkey
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This work investigates the antifungal effect of plasma polymer films produced by low-pressure RF-generated plasma system using acrylic acid, 2–hydroxyethyl methacrylate, and diethyl phosphite (DEP). Unmodified and plasma-modified polystyrene (PS) microplate wells were tested by 30 biofilm-positive Candida spp. isolated from blood samples and two control strains using a quantitative plaque assay method. Regardless of the precursors and plasma parameters, biofilm formation was inhibited for all plasma-modified microplate wells. The most significant anti-biofilm effect was observed on PS modified by DEP at 90 W plasma power with the inhibition of all Candida species’ biofilm formation.

Research Letters
Copyright © The Author(s), 2020, published on behalf of Materials Research Society by Cambridge University Press

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